دورية أكاديمية
Cytokines profile in immunocompetent mice during Trichosporon asahii infection.
| العنوان: | Cytokines profile in immunocompetent mice during Trichosporon asahii infection. |
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| المؤلفون: | Montoya AM; Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León., González GM; Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León., Martinez-Castilla AM; Departamento de Inmunología, Facultad de Medicina, Universidad Autónoma de Nuevo León., Aguilar SA; Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León., Franco-Molina MA; Departamento de Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León., Coronado-Cerda E; Departamento de Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León., Rosas-Taraco AG; Departamento de Inmunología, Facultad de Medicina, Universidad Autónoma de Nuevo León. |
| المصدر: | Medical mycology [Med Mycol] 2018 Jan 01; Vol. 56 (1), pp. 103-109. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9815835 Publication Model: Print Cited Medium: Internet ISSN: 1460-2709 (Electronic) Linking ISSN: 13693786 NLM ISO Abbreviation: Med Mycol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Oxford : Oxford University Press Original Publication: Oxford : Blackwell Science, c1998- |
| مواضيع طبية MeSH: | Cytokines/*analysis , Cytokines/*blood , Trichosporon/*immunology , Trichosporonosis/*pathology, Animal Structures/pathology ; Animals ; Disease Models, Animal ; Male ; Mice, Inbred BALB C ; Neutrophils/immunology ; Serum/chemistry |
| مستخلص: | Trichosporon asahii is an opportunistic yeastlike fungus commonly associated with systemic infections in immunocompromised patients. Neutropenia is recognized as the main risk factor in infections by T. asahii; however, little is known about the cytokine response during trichosporonosis. Here, we evaluated systemic and local cytokine production and histological damage in immunocompetent mice during systemic infection with T. asahii. We found a significant increased presence of G-CSF, TNF-α, IFN-γ, and IL-6 in sera samples. High levels of G-CSF were found in organs (kidney, liver and spleen); meanwhile IL-10, IL-17A, IL-2, IL-4 and TNF-α were found in low levels. Neutrophils and fungal structures were found in early stage in analyzed organs. Our results demonstrated that T. asahii induces a systemic inflammatory response and G-CSF environment in infected organs in immunocompetent mice and neutrophil recruitment in analyzed tissue suggests the importance of these cells for fungal control. (© The Author 2017. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: G-CSF; IFN-γ; IL-6; TNF-α; Trichosporon asahii; cytokine response |
| المشرفين على المادة: | 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20170325 Date Completed: 20180716 Latest Revision: 20180716 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1093/mmy/myx018 |
| PMID: | 28340200 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1460-2709 |
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| DOI: | 10.1093/mmy/myx018 |