دورية أكاديمية
أعرض في EDS

Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria.

التفاصيل البيبلوغرافية
العنوان: Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria.
المؤلفون: Fankam AG; Department of Biochemistry, Faculty of science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Kuiate JR; Department of Biochemistry, Faculty of science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Kuete V; Department of Biochemistry, Faculty of science, University of Dschang, P.O. Box 67, Dschang, Cameroon. kuetevictor@yahoo.fr.
المصدر: BMC complementary and alternative medicine [BMC Complement Altern Med] 2017 Mar 24; Vol. 17 (1), pp. 168. Date of Electronic Publication: 2017 Mar 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088661 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6882 (Electronic) Linking ISSN: 14726882 NLM ISO Abbreviation: BMC Complement Altern Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-2019]
مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Euphorbiaceae/*chemistry , Gram-Negative Bacteria/*drug effects , Plant Extracts/*pharmacology, Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacteria/physiology ; Humans ; Kanamycin/pharmacology ; Microbial Sensitivity Tests ; Plant Bark/chemistry ; Plant Leaves/chemistry ; Tetracycline/pharmacology
مستخلص: Background: Recinodindron heudelotii (Euphorbiaceae) is a plant used in Africa, particularly in Cameroon to treat various ailments including bacterial infections. In this study, we evaluated the extracts of the leaves (RHL) and bark (RHB) of R. heudelotii for their antibacterial and antibiotic resistance modulating activities against 29 Gram-negative bacteria, including multidrug-resistant (MDR) phenotypes.
Methods: The broth micro-dilution assay was used to evaluate the antibacterial activity, and the antibiotic resistance modulating effects of the plant extracts.
Results: RHL displayed the most important spectrum of activity with minimal inhibitory concentrations (MICs) values ranging from 256 to 1024 μg/mL against 75.86% of the 29 tested bacteria strains while RHB was not active. RHL also showed killing effects with minimal bactericidal concentrations (MBCs) ranging from 256 to 1024 μg/mL. The activities of tetracycline and kanamycin associated with RHL were improved on 88.89% and 77.78% of the tested MDR bacteria, at MIC/2 at MIC/4 respectively, with 2 to 16-folds decreasing of MIC. This suggests the antibiotic resistance modulating effects of these antibiotics.
Conclusion: The present study provides data indicating a possible use of the leaves extract of Recinodindron heudelotii alone or in association with common antibiotics in the fight against bacterial infections including those involving MDR bacteria.
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فهرسة مساهمة: Keywords: Recinodindron heudelotii, Gram-negative bacteria, MDR bacteria; antibacterial activity; antibiotic modulators
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Plant Extracts)
59-01-8 (Kanamycin)
F8VB5M810T (Tetracycline)
تواريخ الأحداث: Date Created: 20170326 Date Completed: 20170425 Latest Revision: 20220318
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5366133
DOI: 10.1186/s12906-017-1687-2
PMID: 28340621
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6882
DOI:10.1186/s12906-017-1687-2