دورية أكاديمية
Protective Effect of Cymbopogon citratus Essential Oil in Experimental Model of Acetaminophen-Induced Liver Injury.
| العنوان: | Protective Effect of Cymbopogon citratus Essential Oil in Experimental Model of Acetaminophen-Induced Liver Injury. |
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| المؤلفون: | Uchida NS; Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil., Silva-Filho SE; Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil., Aguiar RP; Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil., Wiirzler LAM; Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil., Cardia GFE; Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil., Cavalcante HAO; Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil., Silva-Comar FMS; Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil., Becker TCA; † Department of Basic Health Science, State University of Maringá, 87020-900 Maringá, PR, Brazil., Silva EL; ‡ Department of Chemistry, State University of Maringá, 87020-900 Maringá, PR, Brazil., Bersani-Amado CA; Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil., Cuman RKN; Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil. |
| المصدر: | The American journal of Chinese medicine [Am J Chin Med] 2017; Vol. 45 (3), pp. 515-532. Date of Electronic Publication: 2017 Mar 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: World Scientific Pub Country of Publication: Singapore NLM ID: 7901431 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1793-6853 (Electronic) Linking ISSN: 0192415X NLM ISO Abbreviation: Am J Chin Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: Singapore ; River Edge, NJ : World Scientific Pub. Original Publication: [Garden City, N.Y.] : Institute for Advanced Research in Asian Science and Medicine |
| مواضيع طبية MeSH: | Phytotherapy*, Acetaminophen/*adverse effects , Analgesics, Non-Narcotic/*adverse effects , Antipyretics/*adverse effects , Chemical and Drug Induced Liver Injury/*etiology , Chemical and Drug Induced Liver Injury/*prevention & control , Cymbopogon/*chemistry , Oils, Volatile/*therapeutic use, Animals ; Chemical and Drug Induced Liver Injury/drug therapy ; Disease Models, Animal ; Male ; Mice ; Oils, Volatile/administration & dosage ; Oils, Volatile/isolation & purification ; Oils, Volatile/pharmacology |
| مستخلص: | To investigate the hepatoprotective effect of Cymbopogon citratus or lemongrass essential oil (LGO), it was used in an animal model of acute liver injury induced by acetaminophen (APAP). Swiss mice were pretreated with LGO (125, 250 and 500[Formula: see text]mg/kg) and SLM (standard drug, 200[Formula: see text]mg/kg) for a duration of seven days, followed by the induction of hepatotoxicity of APAP (single dose, 250[Formula: see text]mg/kg). The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase were determined to evaluate the hepatoprotective effects of the LGO. The livers were used to determine myeloperoxidase (MPO) activity, nitric oxide (NO) production and histological analysis. The effect of LGO on leukocyte migration was evaluated in vitro. Anti-oxidant activity was performed by assessing the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) in vitro. LGO pretreatment decreased significantly the levels of ALT, AST and ALP compared with APAP group. MPO activity and NO production were decreased. The histopathological analysis showed an improved of hepatic lesions in mice after LGO pretreatment. LGO inhibited neutrophil migration and exhibited anti-oxidant activity. Our results suggest that LGO has protective activity against liver toxicity induced by paracetamol. |
| فهرسة مساهمة: | Keywords: Acetaminophen; Acute Liver Injury; Cymbopogon citratus; Essential Oil; Hepatotoxicity; Lemongrass |
| المشرفين على المادة: | 0 (Analgesics, Non-Narcotic) 0 (Antipyretics) 0 (Oils, Volatile) 362O9ITL9D (Acetaminophen) |
| تواريخ الأحداث: | Date Created: 20170401 Date Completed: 20170919 Latest Revision: 20170919 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1142/S0192415X17500318 |
| PMID: | 28359199 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1793-6853 |
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| DOI: | 10.1142/S0192415X17500318 |