دورية أكاديمية
Resurgence of Malaria Following Discontinuation of Indoor Residual Spraying of Insecticide in an Area of Uganda With Previously High-Transmission Intensity.
| العنوان: | Resurgence of Malaria Following Discontinuation of Indoor Residual Spraying of Insecticide in an Area of Uganda With Previously High-Transmission Intensity. |
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| المؤلفون: | Raouf S; Department of Medicine, University of Colorado School of Medicine, Aurora., Mpimbaza A; Child Health & Development Centre, Makerere University College of Health Sciences.; Uganda Malaria Surveillance Project., Kigozi R; Uganda Malaria Surveillance Project., Sserwanga A; Uganda Malaria Surveillance Project., Rubahika D; National Malaria Control Program, Ministry of Health, Kampala, Uganda., Katamba H; National Malaria Control Program, Ministry of Health, Kampala, Uganda., Lindsay SW; School of Biological and Biomedical Sciences, Durham University, United Kingdom., Kapella BK; US President's Malaria Initiative, Malaria Branch, Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention., Belay KA; US Agency for International Development., Kamya MR; School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda., Staedke SG; Department of Clinical Research, London School of Hygiene & Tropical Medicine, United Kingdom., Dorsey G; Department of Medicine, University of California San Francisco. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2017 Aug 01; Vol. 65 (3), pp. 453-460. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Insecticide-Treated Bednets/*statistics & numerical data , Insecticides/*therapeutic use , Malaria/*epidemiology , Malaria/*prevention & control, Adolescent ; Child ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Morbidity ; Uganda/epidemiology |
| مستخلص: | Background: Indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) are the primary tools for malaria prevention in Africa. It is not known whether reductions in malaria can be sustained after IRS is discontinued. Our aim in this study was to assess changes in malaria morbidity in an area of Uganda with historically high transmission where IRS was discontinued after a 4-year period followed by universal LLIN distribution. Methods: Individual-level malaria surveillance data were collected from 1 outpatient department and 1 inpatient setting in Apac District, Uganda, from July 2009 through November 2015. Rounds of IRS were delivered approximately every 6 months from February 2010 through May 2014 followed by universal LLIN distribution in June 2014. Temporal changes in the malaria test positivity rate (TPR) were estimated during and after IRS using interrupted time series analyses, controlling for age, rainfall, and autocorrelation. Results: Data include 65 421 outpatient visits and 13 955 pediatric inpatient admissions for which a diagnostic test for malaria was performed. In outpatients aged <5 years, baseline TPR was 60%-80% followed by a rapid and then sustained decrease to 15%-30%. During the 4-18 months following discontinuation of IRS, absolute TPR values increased by an average of 3.29% per month (95% confidence interval, 2.01%-4.57%), returning to baseline levels. Similar trends were seen in outpatients aged ≥5 years and pediatric admissions. Conclusions: Discontinuation of IRS in an area with historically high transmission intensity was associated with a rapid increase in malaria morbidity to pre-IRS levels. (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com) |
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| معلومات مُعتمدة: | U01 GH000076 United States GH CGH CDC HHS; U19 AI089674 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: IRS; LLIN; Uganda; malaria; resurgence |
| المشرفين على المادة: | 0 (Insecticides) |
| تواريخ الأحداث: | Date Created: 20170404 Date Completed: 20180425 Latest Revision: 20230815 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5850037 |
| DOI: | 10.1093/cid/cix251 |
| PMID: | 28369387 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/cix251 |