دورية أكاديمية
أعرض في EDS

Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction.

التفاصيل البيبلوغرافية
العنوان: Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction.
المؤلفون: Silva-Filho AF; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil., Sena WLB; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil., Lima LRA; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil.; Faculdades Integradas de Patos, Patos, Brazil., Carvalho LVN; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil., Pereira MC; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil.; Department of Physiology and Pharmacology, Federal University of Pernambuco (UFPE), Recife, Brazil., Santos LGS; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil., Santos RVC; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil., Tavares LB; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil., Pitta MGR; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil.; Department of Biochemistry, Federal University of Pernambuco (UFPE), Recife, Brazil., Rêgo MJBM; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Center for Research on Therapeutic Innovation - Suely Galdino (NUPIT-SG-UFPE), Recife, Brazil.; Department of Biochemistry, Federal University of Pernambuco (UFPE), Recife, Brazil.
المصدر: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2017; Vol. 41 (5), pp. 1801-1829. Date of Electronic Publication: 2017 Apr 03.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Cell Physiol Biochem Press GmbH & Co KG Country of Publication: Germany NLM ID: 9113221 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9778 (Electronic) Linking ISSN: 10158987 NLM ISO Abbreviation: Cell Physiol Biochem Subsets: MEDLINE
أسماء مطبوعة: Publication: 2019- : Düsseldorf, Germany : Cell Physiol Biochem Press GmbH & Co KG
Original Publication: Basel ; New York : S. Karger, 1991-2018.
مواضيع طبية MeSH: Hypoxia/*metabolism , Neoplasm Proteins/*metabolism , Neoplasms/*metabolism , Polysaccharides/*metabolism, Animals ; Glucose/metabolism ; Glycosylation ; Humans ; N-Acetylneuraminic Acid/metabolism
مستخلص: Post-translational and co-translational enzymatic addition of glycans (glycosylation) to proteins, lipids, and other carbohydrates, is a powerful regulator of the molecular machinery involved in cell cycle, adhesion, invasion, and signal transduction, and is usually seen in both in vivo and in vitro cancer models. Glycosyltransferases can alter the glycosylation pattern of normal cells, subsequently leading to the establishment and progression of several diseases, including cancer. Furthermore, a growing amount of research has shown that different oxygen tensions, mainly hypoxia, leads to a markedly altered glycosylation, resulting in altered glycan-receptor interactions. Alteration of intracellular glucose metabolism, from aerobic cellular respiration to anaerobic glycolysis, inhibition of integrin 3α1β translocation to the plasma membrane, decreased 1,2-fucosylation of cell-surface glycans, and galectin overexpression are some consequences of the hypoxic tumor microenvironment. Additionally, increased expression of gangliosides carrying N-glycolyl sialic acid can also be significantly affected by hypoxia. For all these reasons, it is possible to realize that hypoxia strongly alters glycobiologic events within tumors, leading to changes in their behavior. This review aims to analyze the complexity and importance of glycoconjugates and their molecular interaction network in the hypoxic context of many solid tumors.
(© 2017 The Author(s)Published by S. Karger AG, Basel.)
فهرسة مساهمة: Keywords: Biomarker; Cancer; Carbohydrate metabolism; Glycobiology; Glycosyltransferases; Hypoxic microenvironment
المشرفين على المادة: 0 (Neoplasm Proteins)
0 (Polysaccharides)
GZP2782OP0 (N-Acetylneuraminic Acid)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20170405 Date Completed: 20170623 Latest Revision: 20190212
رمز التحديث: 20231215
DOI: 10.1159/000471912
PMID: 28376491
قاعدة البيانات: MEDLINE
الوصف
تدمد:1421-9778
DOI:10.1159/000471912