دورية أكاديمية
Modulation of antibiotic activity by the hydroalcoholic extract from leaves of Caryocar coriaceum WITTM.
| العنوان: | Modulation of antibiotic activity by the hydroalcoholic extract from leaves of Caryocar coriaceum WITTM. |
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| المؤلفون: | de Lacerda Neto LJ; a Departamento de Química Biológica , Universidade Regional do Cariri - URCA , Crato , Brasil.; b Unidade Acadêmica Ciências da Vida , Universidade Federal de Campina Grande , Cajazeiras , Brasil., Ramos AGB; a Departamento de Química Biológica , Universidade Regional do Cariri - URCA , Crato , Brasil., Kerntopf MR; a Departamento de Química Biológica , Universidade Regional do Cariri - URCA , Crato , Brasil., Coutinho HDM; a Departamento de Química Biológica , Universidade Regional do Cariri - URCA , Crato , Brasil., Quintans-Junior LJ; c Departamento de Fisiologia , Universidade Federal de Sergipe , São Cristovão , Brasil., Almeida JRGS; d Departamento de Ciências Farmacêuticas , Universidade Federal do Vale do São Francisco , Petrolina , Brasil., Ribeiro-Filho J; e Departamento de Biomedicina , Centro Universitário Dr. Leão Sampaio - UNILEAO , Juazeiro do Norte , Brasil., Menezes IRA; a Departamento de Química Biológica , Universidade Regional do Cariri - URCA , Crato , Brasil. |
| المصدر: | Natural product research [Nat Prod Res] 2018 Feb; Vol. 32 (4), pp. 477-480. Date of Electronic Publication: 2017 Apr 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Ericales/*chemistry , Plant Extracts/*pharmacology, Antioxidants/pharmacology ; Chromatography, Thin Layer ; Drug Evaluation, Preclinical/methods ; Drug Synergism ; Escherichia coli/drug effects ; Flavonoids/analysis ; Microbial Sensitivity Tests ; Phenols/analysis ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Pseudomonas aeruginosa/drug effects ; Quercetin/analysis ; Rutin/analysis ; Staphylococcus aureus/drug effects ; Tannins/analysis |
| مستخلص: | The aim of this study was to identify the presence of tannins, phenols and flavonoids on the hydroalcoholic extract of Caryocar coriaceum leaves (HECCL) and to determine the antioxidant and antibacterial activity of this extract. The extract was tested alone (1024-1 μg/mL) or associated (MIC/8) with several antibiotics in order to identify any antibacterial activity against multiresistant bacterial strains (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa). The existence of tannins, total phenols (901.31 mg/g) and flavonoids (89.68 mg/g) was confirmed in the HECCL. The presence of rutin and quercetin were confirmed by Thin-layer chromatography (TLC). Using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, the antioxidant activity of the extract (9 μg/mL) was determined. Moreover, the Minimum Inhibitory Concentration (MIC) value found for HECCL was 1024 μg/mL and the association between HECCL (MIC/8) with benzylpenicillin significantly changed its minimum inhibitory concentration from 2500 to 625 μg/mL against E. coli. |
| فهرسة مساهمة: | Keywords: Antibiotic; antibiotic modifying activity; pequi; synergism |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Antioxidants) 0 (Flavonoids) 0 (Phenols) 0 (Plant Extracts) 0 (Tannins) 5G06TVY3R7 (Rutin) 9IKM0I5T1E (Quercetin) |
| تواريخ الأحداث: | Date Created: 20170411 Date Completed: 20180319 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/14786419.2017.1312396 |
| PMID: | 28391717 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2017.1312396 |