دورية أكاديمية
Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease.
| العنوان: | Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease. |
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| المؤلفون: | Kash JC; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Walters KA; Institute for Systems Biology, Seattle, WA 98109, USA., Kindrachuk J; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA., Baxter D; Institute for Systems Biology, Seattle, WA 98109, USA., Scherler K; Institute for Systems Biology, Seattle, WA 98109, USA., Janosko KB; Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA., Adams RD; Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA., Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA., James RM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA., Stonier SW; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA., Memoli MJ; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA., Davey RT Jr; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Chertow DS; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA., Taubenberger JK; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. taubenbergerj@niaid.nih.gov. |
| المصدر: | Science translational medicine [Sci Transl Med] 2017 Apr 12; Vol. 9 (385). |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Intramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science |
| مواضيع طبية MeSH: | Ebolavirus/*pathogenicity , Hemorrhagic Fever, Ebola/*virology , Leukocytes/*metabolism, Disease Outbreaks ; Hemorrhagic Fever, Ebola/blood ; Humans ; Longitudinal Studies ; RNA, Viral/blood ; RNA, Viral/genetics ; Virus Replication/physiology |
| مستخلص: | The 2013-2015 outbreak of Ebola virus disease in Guinea, Liberia, and Sierra Leone was unprecedented in the number of documented cases, but there have been few published reports on immune responses in clinical cases and their relationships with the course of illness and severity of Ebola virus disease. Symptoms of Ebola virus disease can include severe headache, myalgia, asthenia, fever, fatigue, diarrhea, vomiting, abdominal pain, and hemorrhage. Although experimental treatments are in development, there are no current U.S. Food and Drug Administration-approved vaccines or therapies. We report a detailed study of host gene expression as measured by microarray in daily peripheral blood samples collected from a patient with severe Ebola virus disease. This individual was provided with supportive care without experimental therapies at the National Institutes of Health Clinical Center from before onset of critical illness to recovery. Pearson analysis of daily gene expression signatures revealed marked gene expression changes in peripheral blood leukocytes that correlated with changes in serum and peripheral blood leukocytes, viral load, antibody responses, coagulopathy, multiple organ dysfunction, and then recovery. This study revealed marked shifts in immune and antiviral responses that preceded changes in medical condition, indicating that clearance of replicating Ebola virus from peripheral blood leukocytes is likely important for systemic viral clearance. (Copyright © 2017, American Association for the Advancement of Science.) |
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| معلومات مُعتمدة: | ZIA AI000986-10 United States Intramural NIH HHS |
| المشرفين على المادة: | 0 (RNA, Viral) |
| تواريخ الأحداث: | Date Created: 20170414 Date Completed: 20170626 Latest Revision: 20191008 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5497219 |
| DOI: | 10.1126/scitranslmed.aai9321 |
| PMID: | 28404864 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.aai9321 |