دورية أكاديمية
Can Ultrasound Imaging Predict the Success of an Experimental Steatofibrosis Model?
| العنوان: | Can Ultrasound Imaging Predict the Success of an Experimental Steatofibrosis Model? |
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| المؤلفون: | Turkay R; Radiology Department, Istanbul Bakirkoy Dr. Sadi Konuk Training and Research Hospital; †Department of Biochemistry, Faculty of Medicine, Istanbul University; ‡Department of Pathology, Faculty of Medicine, Yeditepe University; and §Department of Radiology, Faculty of Medicine, Istanbul University, Istanbul, Turkey., Aydin AF, Bingul I, Kucukgergin C, Dogan-Ekici I, Hocaoglu E, Inci E, Bakir B, Uysal M |
| المصدر: | Ultrasound quarterly [Ultrasound Q] 2017 Jun; Vol. 33 (2), pp. 157-161. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8809459 Publication Model: Print Cited Medium: Internet ISSN: 1536-0253 (Electronic) Linking ISSN: 08948771 NLM ISO Abbreviation: Ultrasound Q Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [New York, N.Y., U.S.A.] : Raven Press, [c1988- |
| مواضيع طبية MeSH: | Carbon Tetrachloride* , Diet, High-Fat* , Disease Models, Animal*, Fatty Liver/*diagnostic imaging , Liver/*diagnostic imaging , Ultrasonography/*methods, Animals ; Female ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Species Specificity |
| مستخلص: | Our goal was to evaluate the role of ultrasound (US) imaging in an experimental 2-hit steatofibrosis rat model. Nineteen female Sprague-Dawley rats were divided into 2 groups: control group (n = 6) and high-fat diet carbontetrachloride (HFD-CCl4) group (n = 13) that was fed with HFD for 14 weeks. Ultrasound was performed to evaluate liver steatosis. The HFD-CCl4 group rats were divided further into 2 subgroups: HFD rats with liver steatosis [US (+) group; n = 6] and without steatosis [US (-) group; n = 7]. All rats in the subgroups were administered with CCl4. In both US (+) and US (-) subgroups, steatosis score, fibrosis score, triglyceride, and hydroxyproline contents were markedly higher compared with the control group. When compared with the US (-) group, triglyceride and hydroxyproline contents were significantly higher in the US (+) group, whereas steatosis and fibrosis scores were not different. Ultrasound imaging may be useful to assess the success of a 2-hit experimental steatofibrosis model. |
| المشرفين على المادة: | CL2T97X0V0 (Carbon Tetrachloride) |
| تواريخ الأحداث: | Date Created: 20170420 Date Completed: 20180312 Latest Revision: 20180312 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/RUQ.0000000000000286 |
| PMID: | 28422772 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-0253 |
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| DOI: | 10.1097/RUQ.0000000000000286 |