دورية أكاديمية
أعرض في EDS

TREM2-Ligand Interactions in Health and Disease.

التفاصيل البيبلوغرافية
العنوان: TREM2-Ligand Interactions in Health and Disease.
المؤلفون: Kober DL; Molecular Microbiology and Microbial Pathogenesis Program, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Brett TJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: tbrett@wustl.edu.
المصدر: Journal of molecular biology [J Mol Biol] 2017 Jun 02; Vol. 429 (11), pp. 1607-1629. Date of Electronic Publication: 2017 Apr 19.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: 1959- : London : Academic Press
مواضيع طبية MeSH: Health*, Membrane Glycoproteins/*metabolism , Neurodegenerative Diseases/*pathology , Receptors, Immunologic/*metabolism, Animals ; Disease Models, Animal ; Humans ; Protein Binding
مستخلص: The protein triggering receptor expressed on myeloid cells-2 (TREM2) is an immunomodulatory receptor with a central role in myeloid cell activation and survival. In recent years, the importance of TREM2 has been highlighted by the identification of coding variants that increase risk for Alzheimer's disease and other neurodegenerative diseases. Animal studies have further shown the importance of TREM2 in neurodegenerative and other inflammatory disease models including chronic obstructive pulmonary disease, multiple sclerosis, and stroke. A mechanistic understanding of TREM2 function remains elusive, however, due in part to the absence of conclusive information regarding the identity of endogenous TREM2 ligands. While many TREM2 ligands have been proposed, their physiological role and mechanism of engagement remain to be determined. In this review, we highlight the suggested roles of TREM2 in these diseases and the recent advances in our understanding of TREM2 and discuss putative TREM2-ligand interactions and their potential roles in signaling during health and disease. We develop a model based on the TREM2 structure to explain how different TREM2 ligands might interact with the receptor and how disease risk variants may alter ligand interactions. Finally, we propose future experimental directions to establish the role and importance of these different interactions on TREM2 function.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: P50 AG005681 United States AG NIA NIH HHS; R01 HL119813 United States HL NHLBI NIH HHS; T32 GM007067 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Alzheimer's disease; immune signaling; inflammation; microglia; neurodegeneration
المشرفين على المادة: 0 (Membrane Glycoproteins)
0 (Receptors, Immunologic)
0 (TREM2 protein, human)
تواريخ الأحداث: Date Created: 20170423 Date Completed: 20170712 Latest Revision: 20190106
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5485854
DOI: 10.1016/j.jmb.2017.04.004
PMID: 28432014
قاعدة البيانات: MEDLINE
الوصف
تدمد:1089-8638
DOI:10.1016/j.jmb.2017.04.004