دورية أكاديمية
أعرض في EDS

Subchronic nandrolone administration reduces cardiac oxidative markers during restraint stress by modulating protein expression patterns.

التفاصيل البيبلوغرافية
العنوان: Subchronic nandrolone administration reduces cardiac oxidative markers during restraint stress by modulating protein expression patterns.
المؤلفون: Pergolizzi B; Cell Biology, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Carriero V; Pharmacology, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Abbadessa G; Pharmacology, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Penna C; Cardiovascular Physiology, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Berchialla P; Unit of Biostatistics, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., De Francia S; Pharmacology, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Bracco E; Cell Biology, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy.; Department of Oncology, University of Torino, Turin, Italy., Racca S; Pharmacology, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy. silvia.racca@unito.it.; School of Medicine, Department of Clinical and Biological Sciences, University of Torino, A.O.U. S. Luigi Gonzaga, Regione Gonzole 10, 10043, Orbassano, Turin, Italy. silvia.racca@unito.it.
المصدر: Molecular and cellular biochemistry [Mol Cell Biochem] 2017 Oct; Vol. 434 (1-2), pp. 51-60. Date of Electronic Publication: 2017 Apr 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: The Hague, Dr. W. Junk B. V. Publishers.
مواضيع طبية MeSH: Immobilization* , Oxidative Stress* , Stress, Physiological*, Anabolic Agents/*pharmacology , Biomarkers/*metabolism , Heart Ventricles/*drug effects , Nandrolone/*administration & dosage, Aldehydes/blood ; Aldehydes/metabolism ; Amino Acids/biosynthesis ; Animals ; Biomarkers/blood ; Blotting, Western ; Electrophoresis, Gel, Two-Dimensional ; Energy Metabolism ; Male ; Malondialdehyde/blood ; Malondialdehyde/metabolism ; Mass Spectrometry ; Rats ; Rats, Sprague-Dawley
مستخلص: Nandrolone decanoate (ND), an anabolic-androgenic steroid prohibited in collegiate and professional sports, is associated with detrimental cardiovascular effects through redox-dependent mechanisms. We previously observed that high-dose short-term ND administration (15 mg/kg for 2 weeks) did not induce left heart ventricular hypertrophy and, paradoxically, improved postischemic response, whereas chronic ND treatment (5 mg/kg twice a week for 10 weeks) significantly reduced the cardioprotective effect of postconditioning, with an increase in infarct size and a decrease in cardiac performance. We wanted to determine whether short-term ND administration could affect the oxidative redox status in animals exposed to acute restraint stress. Our hypothesis was that, depending on treatment schedule, ND may have a double-edged sword effect. Measurement of malondialdehyde and 4-hydroxynonenal, two oxidative stress markers, in rat plasma and left heart ventricular tissue, revealed that the levels of both markers were increased in animals exposed to restraint stress, whereas no increase in marker levels was noted in animals pretreated with ND, indicating a possible protective action of ND against stress-induced oxidative damage. Furthermore, isolation and identification of proteins extracted from the left heart ventricular tissue samples of rats pretreated or not with ND and exposed to acute stress showed a prevalent expression of enzymes involved in amino acid synthesis and energy metabolism. Among other proteins, peroxiredoxin 6 and alpha B-crystallin, both involved in the oxidative stress response, were predominantly expressed in the left heart ventricular tissues of the ND-pretreated rats. In conclusion, ND seems to reduce oxidative stress by inducing the expression of antioxidant proteins in the hearts of restraint-stressed animals, thus contributing to amelioration of postischemic heart performance.
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فهرسة مساهمة: Keywords: Anabolic–androgenic steroids; Heart; Oxidative stress; Proteomics; Restraint stress
المشرفين على المادة: 0 (Aldehydes)
0 (Amino Acids)
0 (Anabolic Agents)
0 (Biomarkers)
4Y8F71G49Q (Malondialdehyde)
6PG9VR430D (Nandrolone)
K1CVM13F96 (4-hydroxy-2-nonenal)
تواريخ الأحداث: Date Created: 20170423 Date Completed: 20180806 Latest Revision: 20181113
رمز التحديث: 20240628
DOI: 10.1007/s11010-017-3036-7
PMID: 28432552
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-4919
DOI:10.1007/s11010-017-3036-7