دورية أكاديمية
أعرض في EDS

Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI.

التفاصيل البيبلوغرافية
العنوان: Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI.
المؤلفون: Otto S; Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, University Hospital Jena Friedrich-Schiller-University Jena, Am Klinikum 1, 07747, Jena, Germany. sylvia.otto@med.uni-jena.de., Nitsche K; Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, University Hospital Jena Friedrich-Schiller-University Jena, Am Klinikum 1, 07747, Jena, Germany., Jung C; Department of Cardiology, Pulmonology, University, Duesseldorf, Medical Faculty and Vascular Diseases, Düsseldorf, Germany., Kryvanos A; UltraOsteon, Mannheim, Germany., Zhylka A; Belarusian State University, Faculty of Applied Mathematics and Computer Science, Minsk, Belarus., Heitkamp K; Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, University Hospital Jena Friedrich-Schiller-University Jena, Am Klinikum 1, 07747, Jena, Germany., Gutiérrez-Chico JL; Cardiology Department, Krankenhaus Frankfurt/Oder, Frankfurt/Oder, Germany., Goebel B; Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, University Hospital Jena Friedrich-Schiller-University Jena, Am Klinikum 1, 07747, Jena, Germany., Schulze PC; Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, University Hospital Jena Friedrich-Schiller-University Jena, Am Klinikum 1, 07747, Jena, Germany., Figulla HR; Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, University Hospital Jena Friedrich-Schiller-University Jena, Am Klinikum 1, 07747, Jena, Germany., Poerner TC; Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, University Hospital Jena Friedrich-Schiller-University Jena, Am Klinikum 1, 07747, Jena, Germany.
المصدر: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2017 Apr 26; Vol. 17 (1), pp. 103. Date of Electronic Publication: 2017 Apr 26.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261 (Electronic) Linking ISSN: 14712261 NLM ISO Abbreviation: BMC Cardiovasc Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Coronary Restenosis/*diagnosis , Elective Surgical Procedures/*adverse effects , Endothelial Progenitor Cells/*pathology , Percutaneous Coronary Intervention/*adverse effects , Plaque, Atherosclerotic/*diagnosis , Stents/*adverse effects , Tomography, Optical Coherence/*methods, Aged ; Algorithms ; Coronary Angiography ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/surgery ; Coronary Restenosis/etiology ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Female ; Flow Cytometry ; Follow-Up Studies ; Humans ; Male ; Plaque, Atherosclerotic/surgery ; Prognosis ; Prosthesis Failure ; Reproducibility of Results ; Time Factors
مستخلص: Background: Endothelial progenitor cells (EPC) are involved in neovascularization and endothelial integrity. They might be protective in atherosclerosis. Optical coherence tomography (OCT) is a precise intracoronary imaging modality that allows assessment of subintimal plaque development. We evaluated the influence of EPC on coronary plaque burden in stable disease and implemented a novel computational plaque analysis algorithm using OCT.
Methods: Forty-three patients (69.8% males, 69.6 ± 7.7 years) were investigated by OCT during re-angiography 6 months after elective stent implantation. Different subpopulations of EPCs were identified by flow cytometry according to their co-expression of antigens (CD34+, CD133+, kinase domain receptor, KDR+). An algorithm was applied to calculate the underlying total plaque burden of the stented segments from OCT images. Plaque morphology was assessed according to international consensus in OCT imaging.
Results: A cumulative sub-strut plaque volume of 10.87 ± 12.7 mm 3 and a sub-stent plaque area of 16.23 ± 17.0 mm 2 were found within the stented vessel segments with no significant differences between different stent types. All EPC subpopulations (mean of EPC levels: CD34+/CD133+: 2.66 ± 2.0%; CD34+/KDR+: 7.50 ± 5.0%; CD34+/CD133+/KDR+: 1.12 ± 1.0%) inversely correlated with the identified underlying total plaque volume and plaque area (p ≤ 0.012).
Conclusions: This novel analysis algorithm allows for the first time comprehensive quantification of coronary plaque burden by OCT and illustration as spread out vessel charts. Increased EPC levels are associated with less sub-stent coronary plaque burden which adds to previous findings of their protective role in atherosclerosis.
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فهرسة مساهمة: Keywords: Coronary plaque; Endothelial progenitor cells; Optical coherence tomography; PCI; atherosclerosis
تواريخ الأحداث: Date Created: 20170427 Date Completed: 20171122 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5405468
DOI: 10.1186/s12872-017-0534-1
PMID: 28441929
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2261
DOI:10.1186/s12872-017-0534-1