دورية أكاديمية
أعرض في EDS

Proportions of circulating follicular helper T cells are reduced and correlate with memory B cells in HIV-infected children.

التفاصيل البيبلوغرافية
العنوان: Proportions of circulating follicular helper T cells are reduced and correlate with memory B cells in HIV-infected children.
المؤلفون: Muema DM; Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Macharia GN; Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Olusola BA; Department of Virology, University of Ibadan, Ibadan, Nigeria., Hassan AS; Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Fegan GW; Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Berkley JA; Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Urban BC; Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.; Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Nduati EW; Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
المصدر: PloS one [PLoS One] 2017 Apr 26; Vol. 12 (4), pp. e0175570. Date of Electronic Publication: 2017 Apr 26 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: B-Lymphocytes/*cytology , HIV Infections/*immunology , Immunologic Memory/*immunology , T-Lymphocytes, Helper-Inducer/*cytology, B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Child ; Child, Preschool ; Flow Cytometry ; HIV Infections/blood ; HIV Infections/pathology ; Humans ; Infant ; Leukocyte Common Antigens/metabolism ; Leukocytes, Mononuclear/cytology ; Multivariate Analysis ; Receptors, CCR7/metabolism ; Receptors, CXCR5/metabolism ; Severity of Illness Index ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism
مستخلص: Introduction: HIV causes defects in memory B cells in children, but the mechanisms of those defects have not been fully elucidated. One possible mechanism is the lack of T-cell help to B cells during immune reactions. However, few studies have assessed the effect of HIV on follicular helper T cells (TFH cells) in children.
Methods: In this study, follicular-homing CD4 T cells and memory B cells were assessed in HIV-infected children and compared with children from the community. CXCR5 and CD45RO were used as markers of follicular-homing T cells and memory T cells, respectively. Memory TFH cells were identified as CD3+CD8-CD4+CXCR5+CD45RO+PD1+. Central memory T cells were identified based on CCR7 expression. Relationship between the proportions of follicular-homing CD4 T cells and memory B cells were determined in multivariable regression models.
Results: Highly viremic HIV-infected children had lower proportions of memory TFH cells when compared with community control children. In multivariable analyses, high proportions of memory TFH cells were associated with increased percentages of resting memory B cells after adjusting for other covariates.
Conclusion: The impact of HIV on follicular helper T cells could influence the accumulation of memory B cells in HIV-infected children.
References: Nat Immunol. 2006 Mar;7(3):302-10. (PMID: 16429138)
J Infect Dis. 2011 Aug 15;204(4):534-43. (PMID: 21791655)
Immunity. 2016 Jan 19;44(1):167-78. (PMID: 26795249)
Immunity. 2013 Oct 17;39(4):758-69. (PMID: 24035365)
J Exp Med. 2013 Jan 14;210(1):143-56. (PMID: 23254284)
Pediatr Infect Dis J. 2009 Apr;28(4):295-9. (PMID: 19258919)
Nat Immunol. 2007 Nov;8(11):1246-54. (PMID: 17906628)
J Acquir Immune Defic Syndr. 2007 Aug 1;45(4):380-8. (PMID: 17468666)
AIDS. 2013 May 15;27(8):1209-17. (PMID: 23343911)
J Immunol. 2015 Aug 1;195(3):1082-91. (PMID: 26116511)
Blood. 2006 Sep 1;108(5):1580-7. (PMID: 16645169)
Pediatrics. 2006 Aug;118(2):e315-22. (PMID: 16847077)
Lancet. 2004 Oct 2-8;364(9441):1236-43. (PMID: 15464184)
Blood. 2010 Dec 16;116(25):5571-9. (PMID: 20837780)
PLoS Pathog. 2014 Jan 30;10(1):e1003853. (PMID: 24497824)
Blood. 2012 Aug 2;120(5):985-93. (PMID: 22692510)
AIDS. 2013 Jan 14;27(2):155-62. (PMID: 23238551)
J Virol. 2014 Nov;88(22):13310-21. (PMID: 25210168)
J Clin Invest. 2012 Sep;122(9):3281-94. (PMID: 22922258)
Nature. 2006 Sep 21;443(7109):350-4. (PMID: 16921384)
J Infect Dis. 2008 Aug 15;198(4):481-5. (PMID: 18582200)
AIDS. 2003 Sep 5;17(13):1881-8. (PMID: 12960820)
Nat Rev Immunol. 2009 Apr;9(4):235-45. (PMID: 19319142)
Vaccine. 2008 Feb 20;26(8):1032-7. (PMID: 18242796)
J Clin Invest. 2012 Sep;122(9):3271-80. (PMID: 22922259)
Immunity. 2011 Jan 28;34(1):108-21. (PMID: 21215658)
Nat Med. 2013 Apr;19(4):494-9. (PMID: 23475201)
Nat Immunol. 2013 Dec;14(12):1256-65. (PMID: 24162774)
J Exp Med. 2003 Dec 15;198(12):1909-22. (PMID: 14676302)
Pediatrics. 1999 Nov;104(5):e56. (PMID: 10545582)
Annu Rev Immunol. 2011;29:621-63. (PMID: 21314428)
Medicine (Baltimore). 2015 Jul;94(27):e1125. (PMID: 26166114)
معلومات مُعتمدة: 083579 United Kingdom WT_ Wellcome Trust; 095068 United Kingdom WT_ Wellcome Trust; United Kingdom WT_ Wellcome Trust; 079082 United Kingdom WT_ Wellcome Trust; 089351 United Kingdom WT_ Wellcome Trust
المشرفين على المادة: 0 (CCR7 protein, human)
0 (CXCR5 protein, human)
0 (Receptors, CCR7)
0 (Receptors, CXCR5)
EC 3.1.3.48 (Leukocyte Common Antigens)
تواريخ الأحداث: Date Created: 20170427 Date Completed: 20170905 Latest Revision: 20240325
رمز التحديث: 20240325
مُعرف محوري في PubMed: PMC5405965
DOI: 10.1371/journal.pone.0175570
PMID: 28445512
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0175570