دورية أكاديمية
Paratubal Cyst Size Correlates With Obesity and Dysregulation of the Wnt Signaling Pathway.
| العنوان: | Paratubal Cyst Size Correlates With Obesity and Dysregulation of the Wnt Signaling Pathway. |
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| المؤلفون: | Dietrich JE; Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas., Adeyemi O; Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas., Hakim J; Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas., Santos X; Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas., Bercaw-Pratt JL; Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas., Bournat JC; Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas., Chen CH; Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas., Jorgez CJ; Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Department of Urology, Baylor College of Medicine, Houston, Texas. Electronic address: cj129804@bcm.edu. |
| المصدر: | Journal of pediatric and adolescent gynecology [J Pediatr Adolesc Gynecol] 2017 Oct; Vol. 30 (5), pp. 571-577. Date of Electronic Publication: 2017 Apr 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 9610774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4332 (Electronic) Linking ISSN: 10833188 NLM ISO Abbreviation: J Pediatr Adolesc Gynecol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001->: New York : Elsevier Science Original Publication: Philadelphia, PA : Chapman & Hall, 1996- |
| مواضيع طبية MeSH: | Hyperandrogenism/*complications , Obesity/*complications , Parovarian Cyst/*complications , Wnt Proteins/*metabolism, Adolescent ; Adult ; Child ; Cohort Studies ; Female ; Hirsutism ; Hospitals, Pediatric ; Humans ; Menarche ; Parovarian Cyst/metabolism ; Parovarian Cyst/surgery ; Prospective Studies ; Wnt Signaling Pathway |
| مستخلص: | Study Objective: Paratubal cysts (PTCs) occur in 7%-10% of women, regardless of age. Although common, PTCs often are found incidentally because of the potential for these cysts to be asymptomatic. The specific aims of the study were to determine if PTC number and size correlated with signs of hyperandrogenism and obesity, as well as to investigate the molecular profiles of these PTCs in samples derived from female adolescents. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: A prospective cohort study was performed in a single children's hospital. Girls 18 years of age or younger who underwent surgery for PTC suspected on the basis of the presence of a persistent adnexal cyst on imaging or a concern for adnexal torsion involving a cyst were consented to participate in the study. Results: Nineteen patients met enrollment criteria with a mean age at menarche of 11.2 ± 1.3 years. Most of the patients (84%; n = 16/19) had adnexal torsion at the time of diagnosis of PTC. Irregular menses and hirsutism was found in 52.6% (n = 10/19) of the patients, among whom 36.8% (n = 7/19) were obese. The mean PTC size was 10.4 ± 4.3 cm with 57.9% (n = 11/19) of the cohort having more than 1 PTC. When patients were compared on the basis of their body mass index, the size of PTCs was significantly larger in the overweight/obese group. The wingless-type (WNT) signaling members catenin beta 1 (CTNBB1) and wingless-type MMTV integration site family, member 7A (WNT7A) were upregulated in 86% (n = 12/14) and 79% (n = 11/14) of the patients, respectively. WNT7A was significantly upregulated in girls with 1 cyst and low body mass index. Conclusion: A correlation exists between obesity, cyst size, and hyperandrogenism. Activation of the WNT/CTNBB1 pathway via WNT7A might play a role in PTC development. (Copyright © 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Androgens; CTNBB1; Obesity; Paratubal cyst; SMAD2; WNT7A |
| المشرفين على المادة: | 0 (WNT7A protein, human) 0 (Wnt Proteins) |
| تواريخ الأحداث: | Date Created: 20170501 Date Completed: 20171016 Latest Revision: 20220408 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jpag.2017.04.002 |
| PMID: | 28456695 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-4332 |
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| DOI: | 10.1016/j.jpag.2017.04.002 |