دورية أكاديمية
أعرض في EDS

The comparative immunology of wild and laboratory mice, Mus musculus domesticus.

التفاصيل البيبلوغرافية
العنوان: The comparative immunology of wild and laboratory mice, Mus musculus domesticus.
المؤلفون: Abolins S; School of Biological Sciences, University of Bristol, Tyndall Avenue, Bristol BS8 1TQ, UK., King EC; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK., Lazarou L; School of Biological Sciences, University of Bristol, Tyndall Avenue, Bristol BS8 1TQ, UK., Weldon L; School of Biological Sciences, University of Bristol, Tyndall Avenue, Bristol BS8 1TQ, UK., Hughes L; School of Biological Sciences, University of Bristol, Tyndall Avenue, Bristol BS8 1TQ, UK., Drescher P; School of Biological Sciences, University of Bristol, Tyndall Avenue, Bristol BS8 1TQ, UK., Raynes JG; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK., Hafalla JCR; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK., Viney ME; School of Biological Sciences, University of Bristol, Tyndall Avenue, Bristol BS8 1TQ, UK., Riley EM; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
المصدر: Nature communications [Nat Commun] 2017 May 03; Vol. 8, pp. 14811. Date of Electronic Publication: 2017 May 03.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Animals, Laboratory/*immunology , Animals, Wild/*immunology , Mice/*immunology, Animals ; Blood Proteins/metabolism ; Cytokines/biosynthesis ; Feces/chemistry ; Flow Cytometry ; Haptoglobins/metabolism ; Homeostasis ; Immunoglobulin A/analysis ; Immunoglobulin E/blood ; Immunoglobulin G/blood ; Immunophenotyping ; Lymphocyte Activation ; Lymphocyte Subsets ; Mice, Inbred C57BL ; Myeloid Cells/immunology ; Serum Amyloid P-Component/metabolism ; Spleen/cytology ; Spleen/drug effects ; Spleen/immunology
مستخلص: The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system.
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معلومات مُعتمدة: NC/L000601/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research
المشرفين على المادة: 0 (Blood Proteins)
0 (Cytokines)
0 (Haptoglobins)
0 (Immunoglobulin A)
0 (Immunoglobulin G)
0 (Serum Amyloid P-Component)
37341-29-0 (Immunoglobulin E)
تواريخ الأحداث: Date Created: 20170504 Date Completed: 20181211 Latest Revision: 20220318
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5418598
DOI: 10.1038/ncomms14811
PMID: 28466840
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/ncomms14811