دورية أكاديمية
أعرض في EDS

miR-10a and miR-204 as a Potential Prognostic Indicator in Low-Grade Gliomas.

التفاصيل البيبلوغرافية
العنوان: miR-10a and miR-204 as a Potential Prognostic Indicator in Low-Grade Gliomas.
المؤلفون: Son JC; Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Busan, Republic of Korea., Jeong HO; Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Busan, Republic of Korea., Park D; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, Republic of Korea.; Center for Convergent Research of Emerging Virus Infection, Koera Research Institute of Chemical Technology, Deajeon, Republic of Korea., No SG; Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Busan, Republic of Korea., Lee EK; Center for Convergent Research of Emerging Virus Infection, Koera Research Institute of Chemical Technology, Deajeon, Republic of Korea., Lee J; Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Busan, Republic of Korea.; Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Republic of Korea., Chung HY; Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Busan, Republic of Korea.; Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Republic of Korea.
المصدر: Cancer informatics [Cancer Inform] 2017 Apr 12; Vol. 16, pp. 1176935117702878. Date of Electronic Publication: 2017 Apr 12 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101258149 Publication Model: eCollection Cited Medium: Print ISSN: 1176-9351 (Print) Linking ISSN: 11769351 NLM ISO Abbreviation: Cancer Inform Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: <2016- > : Thousand Oaks, CA : SAGE Publications
Original Publication: [Auckland, N.Z.] : Libertas Academica, [2005]-
مستخلص: This study aimed to identify and characterize microRNAs (miRNAs) that are related to radiosensitivity in low-grade gliomas (LGGs). The miRNA expression levels in radiosensitive and radioresistant LGGs were compared using The Cancer Genome Atlas database, and differentially expressed miRNAs were identified using the EBSeq package. The miRNA target genes were predicted using Web databases. Fifteen miRNAs were differentially expressed between the groups, with miR-10a and miR-204 being related to overall survival (OS) of patients with LGG. Patients with upregulated miR-10a expression had a higher mortality rate and shorter OS time, whereas patients with downregulated miR-204 expression had a lower mortality rate and longer OS time. Two genes, HSP90AA1 and CREB5 , were targets for both miRNAs. Thus, this study suggests that expression of miR-10a and miR-204 is significantly related to both radiosensitivity and the survival of patients with LGG. These miRNAs could therefore act as clinical biomarkers for LGG prognosis and diagnosis.
Competing Interests: DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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فهرسة مساهمة: Keywords: CREB5; HSP90AA1; low-grade glioma; miRNA; overall survival (OS); radiosensitivity
تواريخ الأحداث: Date Created: 20170505 Latest Revision: 20201001
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5397276
DOI: 10.1177/1176935117702878
PMID: 28469392
قاعدة البيانات: MEDLINE
الوصف
تدمد:1176-9351
DOI:10.1177/1176935117702878