دورية أكاديمية
Effect of acute intraocular pressure elevation on the minimum rim width in normal, ocular hypertensive and glaucoma eyes.
| العنوان: | Effect of acute intraocular pressure elevation on the minimum rim width in normal, ocular hypertensive and glaucoma eyes. |
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| المؤلفون: | Sharma S; Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore., Tun TA; Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore.; Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore., Baskaran M; Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore.; Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore., Atalay E; Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore., Thakku SG; Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore., Liang Z; Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore., Milea D; Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore.; Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore., Strouthidis NG; Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore.; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.; Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, NSW, Australia., Aung T; Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore.; Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Girard MJ; Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore.; Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore. |
| المصدر: | The British journal of ophthalmology [Br J Ophthalmol] 2018 Jan; Vol. 102 (1), pp. 131-135. Date of Electronic Publication: 2017 May 10. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 1992- : London : BMJ Pub. Group Original Publication: 1917-Dec. 1991: London : British Medical Association |
| مواضيع طبية MeSH: | Visual Fields*, Glaucoma/*diagnosis , Intraocular Pressure/*physiology , Ocular Hypertension/*diagnosis , Optic Disk/*pathology , Retinal Ganglion Cells/*pathology , Tomography, Optical Coherence/*methods, Acute Disease ; Aged ; Female ; Follow-Up Studies ; Glaucoma/physiopathology ; Humans ; Male ; Middle Aged ; Ocular Hypertension/physiopathology ; Prospective Studies ; Tonometry, Ocular/methods |
| مستخلص: | Background: To estimate and compare changes in the Bruch's membrane opening-minimum rim width (BMO-MRW) and area in normal, ocular hypertensive and glaucoma eyes following acute elevations in intraocular pressure (IOP). Methods: The optic nerve heads (ONHs) of 104 subjects (31 normals, 20 ocular hypertension (OHT) and 53 with primary glaucoma) were imaged using Spectral-domain optical coherence tomography (OCT; Spectralis, Heidelberg Engineering, Germany). IOP was raised twice by applying a force (0.64 n then 0.9 n) to the anterior sclera using an ophthalmo-dynamometer. After each IOP increment, IOP was held constant, measured with a Tonopen (AVIA applanation tonometer, Reichert, Depew, New York, USA), and ONH was rescanned with OCT. In each OCT volume, BMO-MRW and area were calculated and at each IOP increment. Results: The baseline MRW was significantly smaller in glaucoma subjects (174.3±54.3 µm) compared with normal (287.4±42.2 µm, p<0.001) and OHT subjects (255.4±45.3 µm, p<0.001). MRW of glaucoma subjects was significantly thinner at the first and second IOP elevations than that at baseline (both p<0.01), but no significant change was noted in normal and OHT subjects. There was no significant change of BMO area at acute IOP elevations from baseline in all diagnoses (all p>0.05). Conclusion: Acute IOP elevation leads to compression of the nerve fibre layers of neuroretinal rim in glaucoma subjects only without changing ONH size. This suggests that the neural and connective tissues at ONH level in glaucoma subjects are more susceptible to acute IOP episodes than OHT or normal controls. Competing Interests: Competing interests: None declared. (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.) |
| فهرسة مساهمة: | Keywords: Glaucoma; Imaging; Intraocular pressure |
| تواريخ الأحداث: | Date Created: 20170512 Date Completed: 20171226 Latest Revision: 20180204 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1136/bjophthalmol-2017-310232 |
| PMID: | 28490427 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-2079 |
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| DOI: | 10.1136/bjophthalmol-2017-310232 |