دورية أكاديمية
أعرض في EDS

Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI.

التفاصيل البيبلوغرافية
العنوان: Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI.
المؤلفون: Blanken AE; Department of Psychology, University of Southern California, Los Angeles, CA, USA., Hurtz S; Drexel University College of Medicine, Philadelphia, PA, USA., Zarow C; Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA., Biado K; Department of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USA., Honarpisheh H; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Somme J; Department of Neurology, Barakaldo, Basque Country, Spain., Brook J; Department of Medicine - Statistics Core, UCLA, Los Angeles, CA, USA., Tung S; Department of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USA., Kraft E; University of Rochester, Rochester, N.Y, USA., Lo D; Department of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USA., Ng DW; Department of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USA., Vinters HV; Department of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USA., Apostolova LG; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: lapostol@iu.edu.
المصدر: NeuroImage. Clinical [Neuroimage Clin] 2017 Apr 21; Vol. 15, pp. 56-61. Date of Electronic Publication: 2017 Apr 21 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101597070 Publication Model: eCollection Cited Medium: Internet ISSN: 2213-1582 (Electronic) Linking ISSN: 22131582 NLM ISO Abbreviation: Neuroimage Clin Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier
مواضيع طبية MeSH: Alzheimer Disease/*diagnostic imaging , Hippocampus/*diagnostic imaging , Magnetic Resonance Imaging/*statistics & numerical data , Temporal Lobe/*diagnostic imaging, Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/pathology ; Atrophy/diagnostic imaging ; Atrophy/pathology ; Cohort Studies ; Female ; Hippocampus/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Temporal Lobe/pathology ; Young Adult
مستخلص: Hippocampal atrophy, amyloid plaques, and neurofibrillary tangles are established pathologic markers of Alzheimer's disease. We analyzed the temporal lobes of 9 Alzheimer's dementia (AD) and 7 cognitively normal (NC) subjects. Brains were scanned post-mortem at 7 Tesla. We extracted hippocampal volumes and radial distances using automated segmentation techniques. Hippocampal slices were stained for amyloid beta (Aβ), tau, and cresyl violet to evaluate neuronal counts. The hippocampal subfields, CA1, CA2, CA3, CA4, and subiculum were manually traced so that the neuronal counts, Aβ, and tau burden could be obtained for each region. We used linear regression to detect associations between hippocampal atrophy in 3D, clinical diagnosis and total as well as subfield pathology burden measures. As expected, we found significant correlations between hippocampal radial distance and mean neuronal count, as well as diagnosis. There were subfield specific associations between hippocampal radial distance and tau in CA2, and cresyl violet neuronal counts in CA1 and subiculum. These results provide further validation for the European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP).
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معلومات مُعتمدة: K02 AG048240 United States AG NIA NIH HHS; P50 AG016570 United States AG NIA NIH HHS; R01 AG040770 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Alzheimer's disease; Brain atrophy; Hippocampus; Imaging; MRI; Neuropathology
تواريخ الأحداث: Date Created: 20170512 Date Completed: 20180302 Latest Revision: 20220408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5412112
DOI: 10.1016/j.nicl.2017.04.020
PMID: 28491492
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-1582
DOI:10.1016/j.nicl.2017.04.020