دورية أكاديمية
أعرض في EDS

Colistin use in critically ill neonates: A case-control study.

التفاصيل البيبلوغرافية
العنوان: Colistin use in critically ill neonates: A case-control study.
المؤلفون: İpek MS; Division of Neonatology, Department of Pediatrics, Memorial Dicle Hospital, Diyarbakir, Turkey. Electronic address: md.msipek@yahoo.com., Aktar F; Department of Pediatrics, Dicle University Faculty of Medicine, Diyarbakir, Turkey. Electronic address: fesihaktar@yahoo.com., Okur N; Department of Pediatrics, Maternity and Children's Hospital, Diyarbakir, Turkey. Electronic address: n.matur@hotmail.com., Celik M; Division of Neonatology, Department of Pediatrics, Diyarbakir Children's Hospital, Diyarbakir, Turkey. Electronic address: mehdincelik@hotmail.com., Ozbek E; Department of Microbiology, Maternity and Children's Hospital, Diyarbakir, Turkey. Electronic address: erdalozbek@outlook.com.
المصدر: Pediatrics and neonatology [Pediatr Neonatol] 2017 Dec; Vol. 58 (6), pp. 490-496. Date of Electronic Publication: 2017 Mar 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Singapore NLM ID: 101484755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-1692 (Electronic) Linking ISSN: 18759572 NLM ISO Abbreviation: Pediatr Neonatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Singapore] : Elsevier
مواضيع طبية MeSH: Critical Illness*, Anti-Bacterial Agents/*therapeutic use , Colistin/*therapeutic use , Cross Infection/*drug therapy, Acute Kidney Injury/chemically induced ; Case-Control Studies ; Colistin/adverse effects ; Drug Resistance, Multiple, Bacterial ; Female ; Humans ; Infant, Newborn ; Male
مستخلص: Background: The aim of this study was to assess the safety and efficacy of colistin use in critically ill neonates.
Methods: This was a case-control study that included newborn infants with proven or suspected nosocomial infections between January 2012 and October 2015, at two centers in Diyarbakir, Turkey. The clinical and laboratory characteristics and outcomes of patients who received colistin therapy were reviewed and compared to patients who were treated with antimicrobial agents other than colistin during the same period.
Results: Forty-seven cases who received intravenous colistin (colistin group) and 59 control patients (control group) were included. There were no significant differences between the groups regarding outcomes and nephrotoxicity, including acute renal failure. Colistin therapy was associated with significantly reduced serum magnesium (1.38 ± 0.39 mg/dL vs. 1.96 ± 0.39 mg/dL, p < 0.001) and hypokalemia (46.8% vs. 25.4%, p = 0.026). The patients who received colistin also had longer hospital stays (43 (32-70) days vs. 39 (28-55) days, p = 0.047), a higher rate of previous carbapenem exposure (40.4% vs. 11.9%, p = 0.001), and a higher age at the onset of infection (13 (10-21) days vs. 11 (9-15) days, p = 0.03).
Conclusion: This study showed that colistin was both effective and safe for treating neonatal infections caused by multidrug-resistant gram-negative bacteria. However, intravenous colistin use was significantly associated with hypomagnesemia and hypokalemia.
(Copyright © 2017. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: colistin; gram-negative bacteria; multi-drug resistant; neonate; nosocomial infection
المشرفين على المادة: 0 (Anti-Bacterial Agents)
Z67X93HJG1 (Colistin)
تواريخ الأحداث: Date Created: 20170515 Date Completed: 20180620 Latest Revision: 20180816
رمز التحديث: 20231215
DOI: 10.1016/j.pedneo.2016.10.002
PMID: 28501490
قاعدة البيانات: MEDLINE
الوصف
تدمد:2212-1692
DOI:10.1016/j.pedneo.2016.10.002