دورية أكاديمية
Significance of Anti-C1q Antibodies in Patients with Systemic Lupus Erythematosus as A Marker of Disease Activity and Lupus Nephritis.
| العنوان: | Significance of Anti-C1q Antibodies in Patients with Systemic Lupus Erythematosus as A Marker of Disease Activity and Lupus Nephritis. |
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| المؤلفون: | Soliman AF; Department of Rheumatology & Rehabilitation,Faculty of Medicine, Benha University, Benha, Egypt., Egailla SE; Department of Rheumatology & Rehabilitation,Faculty of Medicine, Benha University, Benha, Egypt., Abdel-Gawad ER; Department of Clinical & Chemical Pathology,Faculty of Medicine, Benha University, Benha, Egypt., Mansour AI; Department of Clinical & Chemical Pathology,Faculty of Medicine, Benha University, Benha, Egypt., ElKhouly TH; Department of Radiology,Faculty of Medicine, Benha University, Benha, Egypt., Mahgoub MY; Department of Rheumatology & Rehabilitation,Faculty of Medicine, Benha University, Benha, Egypt. |
| المصدر: | The Egyptian journal of immunology [Egypt J Immunol] 2016 Jan; Vol. 23 (1), pp. 107-116. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Modern Commercial Press Country of Publication: Egypt NLM ID: 9816016 Publication Model: Print Cited Medium: Print ISSN: 1110-4902 (Print) NLM ISO Abbreviation: Egypt J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cairo : Modern Commercial Press, |
| مواضيع طبية MeSH: | Complement C1q*, Antibodies, Antinuclear/*blood , Lupus Nephritis/*blood , Lupus Nephritis/*diagnosis, Adult ; Biomarkers/blood ; Female ; Humans ; Lupus Nephritis/pathology ; Male |
| مستخلص: | Anti-C1q autoantibodies have been proposed as a useful marker in SLE. This study aimed at measuring serum levels of anti-C1q antibodies in patients with SLE and investigates correlations of this level with the histopathological classes of renal biopsies and disease activity. The anti-C1q antibody level was measured in 30 females SLE patients and 20 controls. The activity of SLE disease was calculated according to the SLE disease activity index. A renal biopsy from patients with clinical manifestations of renal disease was obtained. There was a significant increase in the level of anti-C1q antibodies in SLE patients than controls and in patients with active LN than inactive LN (P<0.05). There were significant positive correlations between anti-C1q antibody level and SLEDAI & rSLEDAI scores and activity index score of renal biopsies. Anti-C1q antibodies showed higher diagnostic sensitivity and specificity than anti-dsDNA antibodies. In conclusion, anti-C1q antibodies are useful and sensitive non-invasive biomarker with high specificity in combination with anti-dsDNA antibodies for the diagnosis of renal disease activity. (Copyright© by the Egyptian Association of Immunologists.) |
| المشرفين على المادة: | 0 (Antibodies, Antinuclear) 0 (Biomarkers) 80295-33-6 (Complement C1q) |
| تواريخ الأحداث: | Date Created: 20170515 Date Completed: 20171120 Latest Revision: 20171128 |
| رمز التحديث: | 20231215 |
| PMID: | 28502158 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1110-4902 |
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