دورية أكاديمية
[Adrenoreceptive structures in the early embryos of the clawed toad (Xenopus laevis)].
| العنوان: | [Adrenoreceptive structures in the early embryos of the clawed toad (Xenopus laevis)]. |
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| عنوان ترانسليتريتد: | Adrenoretseptivnye struktury v rannikh zarodyshakh shportsevoĭ liagushki (Xenopus laevis). |
| المؤلفون: | Shmukler IuB, Grigor'ev NG, Moskovkin GN |
| المصدر: | Zhurnal evoliutsionnoi biokhimii i fiziologii [Zh Evol Biokhim Fiziol] 1988 Sep-Oct; Vol. 24 (5), pp. 621-4. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 21820250R Publication Model: Print Cited Medium: Print ISSN: 0044-4529 (Print) Linking ISSN: 00444529 NLM ISO Abbreviation: Zh Evol Biokhim Fiziol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moscow Izdatelstvo Nauka |
| مواضيع طبية MeSH: | Receptors, Adrenergic, beta/*metabolism , Xenopus laevis/*metabolism, Animals ; Cleavage Stage, Ovum/metabolism ; Dihydroalprenolol/pharmacokinetics ; Epinephrine/pharmacokinetics ; Iodine Radioisotopes ; Iodocyanopindolol ; Ligands ; Mitochondria/metabolism ; Pindolol/analogs & derivatives ; Pindolol/pharmacokinetics ; Propranolol/pharmacokinetics ; Temperature ; Tritium ; Xenopus laevis/embryology |
| مستخلص: | Studies have been made on the binding of labeled ligands to beta-adrenoreceptor--3H-dihydroalprenolol (DHA) and 125I-iodocyanopindolol (ICP--in crude homogenate and subcellular fractions of toad embryos during cleavage divisions. Specific binding of these ligands was observed which is confirmed by a decrease of the activity after addition of cold propranolol or adrenalin. The value of Kd for DHA is equal to 3 x 10(-9) M for ICP--to 1.5 x 10(-9) M. In addition to this high-affinity pool of binding with a low capacity, a low-affinity and high-capacity pool was also found. Cooling of the preparation up to 4 degrees C for 2 h increases the specific binding simultaneously with a decrease of the affinity of adrenoreceptive structures of the embryo. The data obtained are discussed in relation to the criteria of intracellular transmitter process. |
| المشرفين على المادة: | 0 (Iodine Radioisotopes) 0 (Ligands) 0 (Receptors, Adrenergic, beta) 10028-17-8 (Tritium) 60106-89-0 (Dihydroalprenolol) 83498-72-0 (Iodocyanopindolol) 9Y8NXQ24VQ (Propranolol) BJ4HF6IU1D (Pindolol) YKH834O4BH (Epinephrine) |
| تواريخ الأحداث: | Date Created: 19880901 Date Completed: 19890306 Latest Revision: 20151119 |
| رمز التحديث: | 20240627 |
| PMID: | 2851241 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0044-4529 |
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