دورية أكاديمية
The Absence of Quadrupolar Nuclei Facilitates Efficient 13 C Hyperpolarization via Reversible Exchange with Parahydrogen.
العنوان: | The Absence of Quadrupolar Nuclei Facilitates Efficient 13 C Hyperpolarization via Reversible Exchange with Parahydrogen. |
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المؤلفون: | Barskiy DA; Vanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Department of Physics, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, United States., Shchepin RV; Vanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Department of Physics, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, United States., Tanner CPN; Departments of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA., Colell JFP; Departments of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA., Goodson BM; Southern Illinois University, Department of Chemistry and Biochemistry, Materials Technology Center, Carbondale, IL, 62901, United States., Theis T; Departments of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA., Warren WS; Departments of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA., Chekmenev EY; Vanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Department of Physics, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, United States.; Russian Academy of Sciences, Leninskiy Prospekt 14, 119991, Moscow, Russia. |
المصدر: | Chemphyschem : a European journal of chemical physics and physical chemistry [Chemphyschem] 2017 Jun 20; Vol. 18 (12), pp. 1493-1498. Date of Electronic Publication: 2017 May 18. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100954211 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7641 (Electronic) Linking ISSN: 14394235 NLM ISO Abbreviation: Chemphyschem Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Weinheim, Germany : Wiley-VCH Verlag, c2000- |
مواضيع طبية MeSH: | Magnetic Resonance Imaging*, Organometallic Compounds/*chemistry , Pyridines/*chemistry, Carbon Isotopes ; Nitrogen Isotopes ; Organometallic Compounds/chemical synthesis |
مستخلص: | Nuclear spin hyperpolarization techniques are revolutionizing the field of 13 C molecular MRI. While dissolution dynamic nuclear polarization (d-DNP) is currently the leading technique, it is generally slow (requiring ≈1 h) and costly (≈$USD10 6 ). As a consequence of carbon's central place in biochemistry, tremendous progress using 13 C d-DNP bioimaging has been demonstrated to date including a number of clinical trials. Despite numerous attempts to develop alternatives to d-DNP, the competing methods have faced significant translational challenges. Efficient hyperpolarization of 15 N, 31 P, and other heteronuclei using signal amplification by reversible exchange (SABRE) has been reported in 2015, but extension of this technique to 13 C has proven to be challenging. Here, we present efficient hyperpolarization of 13 C nuclei using micro-Tesla SABRE. Up to ca. 6700-fold enhancement of nuclear spin polarization at 8.45 T is achieved within seconds, corresponding to P (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.) |
فهرسة مساهمة: | Keywords: NMR; carbon-13; hyperpolarization; parahydrogen; spectroscopy |
المشرفين على المادة: | 0 (Carbon Isotopes) 0 (Nitrogen Isotopes) 0 (Organometallic Compounds) 0 (Pyridines) NH9L3PP67S (pyridine) |
تواريخ الأحداث: | Date Created: 20170519 Date Completed: 20180213 Latest Revision: 20180213 |
رمز التحديث: | 20221213 |
DOI: | 10.1002/cphc.201700416 |
PMID: | 28517362 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1439-7641 |
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DOI: | 10.1002/cphc.201700416 |