دورية أكاديمية
Design and characterization of a novel nickel-free cobalt-base alloy for intravascular stents.
| العنوان: | Design and characterization of a novel nickel-free cobalt-base alloy for intravascular stents. |
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| المؤلفون: | Wang Q; School of Stomatology, China Medical University, Shenyang 110002, China; School of Materials Science and Engineering, Shenyang University of Technology, Shenyang 110870, China; Shenyang Dalu Laser Group Co., Ltd., Shenyang 110002, China. Electronic address: mfqwang@163.com., Ren Y; Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China., Babar Shahzad M; Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China., Zhang W; School of Stomatology, China Medical University, Shenyang 110002, China., Pan X; School of Stomatology, China Medical University, Shenyang 110002, China., Zhang S; School of Materials Science and Engineering, Shenyang University of Technology, Shenyang 110870, China., Zhang D; School of Stomatology, China Medical University, Shenyang 110002, China. |
| المصدر: | Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2017 Aug 01; Vol. 77, pp. 565-571. Date of Electronic Publication: 2017 Apr 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101484109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0191 (Electronic) Linking ISSN: 09284931 NLM ISO Abbreviation: Mater Sci Eng C Mater Biol Appl Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: | Alloys/*chemistry, Cobalt ; Corrosion ; Humans ; Nickel ; Stents |
| مستخلص: | Co-Cr-W-Ni alloy (L605) with high tensile strength is used in coronary stents. The thickness of individual strut of the stent is reduced which can decrease the stent restenosis rate. However, about 10% Ni element content in L605 is found to cause allergic reactions and pulmonary embolism, similar to the traditional 316L stainless steel. In this study, a novel nickel-free cobalt-base alloy Co-20Cr-12Fe-18Mn-2Mo-4W-N (wt%) was designed and fabricated in order to efficiently avoid the potential hazards of Ni element. Fe and Mn, essential elements of human body, were added in the alloy to substitute part of Co element. In comparison to L605 alloy, the tensile strength of the new alloy was higher than 1000MPa while elongation was above 55%. The pitting potential of the new alloy was measured close to 1000mV, also higher than that of L605 alloy. CCK-8 test indicated that the cytotoxicity of the new alloy is grade 1, reflecting that Co-20Cr-12Fe-18Mn-2Mo-4W-N alloy has no cytotoxic effects. There was no significant difference in the apoptosis rates between Co-20Cr-12Fe-18Mn-2Mo-4W-N and L605 alloy. The newly developed cobalt-base alloy showed excellent mechanical, corrosion resistance and biological properties, which could make it a desirable material for future clinical investigations. (Copyright © 2017 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cobalt-base alloy; Cytotoxicity; Intravascular stent; Nickel-free |
| المشرفين على المادة: | 0 (Alloys) 3G0H8C9362 (Cobalt) 7OV03QG267 (Nickel) |
| تواريخ الأحداث: | Date Created: 20170524 Date Completed: 20180209 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.msec.2017.03.304 |
| PMID: | 28532066 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-0191 |
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| DOI: | 10.1016/j.msec.2017.03.304 |