دورية أكاديمية
أعرض في EDS

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice.

التفاصيل البيبلوغرافية
العنوان: mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice.
المؤلفون: Burke LK; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Darwish T; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Cavanaugh AR; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Virtue S; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Roth E; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Morro J; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Liu SM; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Xia J; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom., Dalley JW; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom., Burling K; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Chua S; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Vidal-Puig T; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Schwartz GJ; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Blouet C; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
المصدر: ELife [Elife] 2017 May 23; Vol. 6. Date of Electronic Publication: 2017 May 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Energy Metabolism*, Agouti-Related Protein/*metabolism , Mechanistic Target of Rapamycin Complex 1/*metabolism , Neurons/*physiology, Adipose Tissue/physiology ; Animals ; Mice ; Signal Transduction ; Thermogenesis
مستخلص: Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts.
References: Cell Metab. 2007 Jun;5(6):438-49. (PMID: 17550779)
J Pharmacol Exp Ther. 1966 Dec;154(3):493-8. (PMID: 5928249)
Biochim Biophys Acta. 2012 Oct;1817(10 ):1759-67. (PMID: 22531154)
Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R37-48. (PMID: 22012701)
Cell. 2014 Oct 9;159(2):306-17. (PMID: 25303527)
Cell. 2015 Feb 26;160(5):829-41. (PMID: 25703096)
Am J Physiol Regul Integr Comp Physiol. 2012 Aug 15;303(4):R438-48. (PMID: 22761182)
Biochim Biophys Acta. 2013 May;1831(5):943-9. (PMID: 23353596)
Endocrinology. 1999 Mar;140(3):1408-15. (PMID: 10067869)
Cell. 2016 Mar 24;165(1):125-38. (PMID: 27015310)
Science. 2006 May 12;312(5775):927-30. (PMID: 16690869)
Neuroendocrinology. 1999 Nov;70(5):306-16. (PMID: 10567856)
Nat Neurosci. 2015 Jun;18(6):863-71. (PMID: 25915476)
Neuroscience. 2004;126(1):229-40. (PMID: 15145088)
Cell Metab. 2012 Nov 7;16(5):579-87. (PMID: 23123165)
Science. 2002 Aug 2;297(5582):843-5. (PMID: 12161655)
J Neurosci. 2016 May 4;36(18):5034-46. (PMID: 27147656)
Neuropsychopharmacology. 2002 Jun;26(6):716-28. (PMID: 12007742)
Cell. 2012 Oct 26;151(3):645-57. (PMID: 23101631)
Circ Res. 2011 Apr 1;108(7):808-12. (PMID: 21311043)
Cell Metab. 2014 Apr 1;19(4):722-30. (PMID: 24703703)
Nat Neurosci. 2014 Dec;17(12):1830-9. (PMID: 25362474)
Curr Biol. 2002 Apr 16;12(8):632-9. (PMID: 11967149)
Nat Neurosci. 2008 Sep;11(9):998-1000. (PMID: 19160495)
Obesity (Silver Spring). 2009 Jul;17(7):1312-7. (PMID: 19214174)
Nat Neurosci. 2011 Mar;14(3):351-5. (PMID: 21209617)
Cell. 2012 Nov 21;151(5):1126-37. (PMID: 23178128)
Compr Physiol. 2014 Oct;4(4):1677-713. (PMID: 25428857)
J Neurosci. 2011 Aug 24;31(34):12189-97. (PMID: 21865462)
Endocrinology. 2007 Nov;148(11):5339-47. (PMID: 17702843)
Biochem Biophys Res Commun. 2015 Aug 21;464(2):480-6. (PMID: 26159924)
PLoS One. 2012;7(9):e45167. (PMID: 23028821)
Cell Metab. 2013 Feb 5;17 (2):236-48. (PMID: 23395170)
Cell Metab. 2014 Oct 7;20(4):565-72. (PMID: 25295786)
Nat Neurosci. 2005 Oct;8(10):1289-91. (PMID: 16158063)
Cell Metab. 2009 Feb;9(2):203-9. (PMID: 19187776)
Mol Cell Endocrinol. 2010 Apr 29;318(1-2):34-43. (PMID: 19747957)
Am J Physiol Endocrinol Metab. 2000 Oct;279(4):E838-45. (PMID: 11001766)
Physiol Rev. 2004 Jan;84(1):277-359. (PMID: 14715917)
J Neurosci. 2014 Jul 23;34(30):9982-94. (PMID: 25057200)
Neuron. 2009 Jul 16;63(1):27-39. (PMID: 19607790)
J Neurosci. 2008 Jul 9;28(28):7202-8. (PMID: 18614690)
J Clin Invest. 2011 Apr;121(4):1424-8. (PMID: 21364278)
Regul Pept. 2005 Aug 15;130(1-2):97-103. (PMID: 15946750)
Cell Rep. 2015 Apr 21;11(3):335-43. (PMID: 25865886)
Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R831-43. (PMID: 19129373)
Nature. 2008 Aug 14;454(7206):846-51. (PMID: 18668043)
Endocrinology. 2009 Oct;150(10):4541-51. (PMID: 19628573)
Cell Rep. 2016 Feb 23;14 (7):1621-31. (PMID: 26876182)
J Neuroendocrinol. 2015 Jun;27(6):389-98. (PMID: 25925636)
Cell Metab. 2008 Dec;8(6):459-67. (PMID: 19041762)
Nat Neurosci. 2014 Jul;17(7):911-3. (PMID: 24908101)
Neurosci Lett. 2003 Oct 2;349(2):75-8. (PMID: 12946556)
J Exp Biol. 2011 Jan 15;214(Pt 2):242-53. (PMID: 21177944)
J Biol Chem. 2011 Mar 18;286(11):8798-809. (PMID: 21209093)
Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1445-52. (PMID: 18321949)
J Neurosci. 2012 Jul 18;32(29):9870-7. (PMID: 22815502)
Obes Res. 2001 Aug;9(8):462-9. (PMID: 11500526)
Science. 2005 Oct 28;310(5748):683-5. (PMID: 16254186)
N Engl J Med. 1995 Mar 9;332(10):621-8. (PMID: 7632212)
Hypertension. 2007 Mar;49(3):647-52. (PMID: 17190874)
Mol Metab. 2013 Oct 17;3(1):64-72. (PMID: 24567905)
Am J Clin Nutr. 2013 Jul;98(1):57-64. (PMID: 23719558)
JAMA. 1999 Oct 27;282(16):1568-75. (PMID: 10546697)
Int J Obes Relat Metab Disord. 2003 Apr;27(4):530-3. (PMID: 12664087)
Am J Physiol Regul Integr Comp Physiol. 2004 May;286(5):R832-7. (PMID: 14742306)
معلومات مُعتمدة: MR/M501736/1 United Kingdom MRC_ Medical Research Council; R01 DK105441 United States DK NIDDK NIH HHS; MC_UU_12012/2 United Kingdom MRC_ Medical Research Council; G0802051 United Kingdom MRC_ Medical Research Council; P30 DK020541 United States DK NIDDK NIH HHS; MR/N003276/1 United Kingdom MRC_ Medical Research Council; MC_UU_12012/1 United Kingdom MRC_ Medical Research Council; MC_UU_12012/5 United Kingdom MRC_ Medical Research Council; P30 DK026687 United States DK NIDDK NIH HHS; United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: brown fat; energy expenditure; human biology; hypothalamus; mTORC1; medicine; mouse; neuroscience; nutrient-sensing; obesity
المشرفين على المادة: 0 (Agouti-Related Protein)
0 (Agrp protein, mouse)
EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
تواريخ الأحداث: Date Created: 20170524 Date Completed: 20180212 Latest Revision: 20230804
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5441868
DOI: 10.7554/eLife.22848
PMID: 28532548
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.22848