دورية أكاديمية
mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice.
العنوان: | mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. |
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المؤلفون: | Burke LK; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Darwish T; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Cavanaugh AR; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Virtue S; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Roth E; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Morro J; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Liu SM; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Xia J; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom., Dalley JW; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom., Burling K; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Chua S; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Vidal-Puig T; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Schwartz GJ; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Blouet C; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom. |
المصدر: | ELife [Elife] 2017 May 23; Vol. 6. Date of Electronic Publication: 2017 May 23. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
مواضيع طبية MeSH: | Energy Metabolism*, Agouti-Related Protein/*metabolism , Mechanistic Target of Rapamycin Complex 1/*metabolism , Neurons/*physiology, Adipose Tissue/physiology ; Animals ; Mice ; Signal Transduction ; Thermogenesis |
مستخلص: | Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts. |
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معلومات مُعتمدة: | MR/M501736/1 United Kingdom MRC_ Medical Research Council; R01 DK105441 United States DK NIDDK NIH HHS; MC_UU_12012/2 United Kingdom MRC_ Medical Research Council; G0802051 United Kingdom MRC_ Medical Research Council; P30 DK020541 United States DK NIDDK NIH HHS; MR/N003276/1 United Kingdom MRC_ Medical Research Council; MC_UU_12012/1 United Kingdom MRC_ Medical Research Council; MC_UU_12012/5 United Kingdom MRC_ Medical Research Council; P30 DK026687 United States DK NIDDK NIH HHS; United Kingdom WT_ Wellcome Trust |
فهرسة مساهمة: | Keywords: brown fat; energy expenditure; human biology; hypothalamus; mTORC1; medicine; mouse; neuroscience; nutrient-sensing; obesity |
المشرفين على المادة: | 0 (Agouti-Related Protein) 0 (Agrp protein, mouse) EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1) |
تواريخ الأحداث: | Date Created: 20170524 Date Completed: 20180212 Latest Revision: 20230804 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5441868 |
DOI: | 10.7554/eLife.22848 |
PMID: | 28532548 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2050-084X |
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DOI: | 10.7554/eLife.22848 |