دورية أكاديمية
BRMS1 gene expression may be associated with clinico-pathological features of breast cancer.
| العنوان: | BRMS1 gene expression may be associated with clinico-pathological features of breast cancer. |
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| المؤلفون: | Lin LZ; Department of Oncology, Taizhou Central Hospital, Taizhou 318000, P.R. China., Cai MG; Department of Oncology, Luqiao Branch of Taizhou Hospital, Taizhou 318000, P.R. China., Dai YC; Department of Oncology, Taizhou Central Hospital, Taizhou 318000, P.R. China., Zheng ZB; Department of Oncology, Taizhou Central Hospital, Taizhou 318000, P.R. China., Jiang FF; Department of Oncology, Taizhou Central Hospital, Taizhou 318000, P.R. China., Shi LL; Department of Infection, Luqiao Branch of Taizhou Hospital, Taizhou 318000, P.R. China., Pan Y; Department of Oncology, Taizhou Central Hospital, Taizhou 318000, P.R. China yinpanypp@163.com., Song HB; Department of Infection, Luqiao Branch of Taizhou Hospital, Taizhou 318000, P.R. China. |
| المصدر: | Bioscience reports [Biosci Rep] 2017 Aug 21; Vol. 37 (4). Date of Electronic Publication: 2017 Aug 21 (Print Publication: 2017). |
| نوع المنشور: | Journal Article; Meta-Analysis |
| اللغة: | English |
| بيانات الدورية: | Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Portland Press on behalf of the Biochemical Society Original Publication: London : The Biochemical Society, c1981- |
| مواضيع طبية MeSH: | Biomarkers, Tumor/*genetics , Breast Neoplasms/*genetics , Breast Neoplasms/*pathology , Lymph Nodes/*pathology , Repressor Proteins/*genetics, Case-Control Studies ; Confidence Intervals ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphatic Metastasis ; Neoplasm Staging ; Odds Ratio ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Statistics as Topic |
| مستخلص: | Our aim is to investigate whether or not the breast cancer metastasis suppressor 1 ( BRMS1 ) gene expression is directly linked to clinico-pathological features of breast cancer. Following a stringent inclusion and exclusion criteria, case-control studies with associations between BRMS1 and breast cancer were selected from articles obtained by way of searches conducted through an electronic database. All statistical analyses were performed with Stata 12.0 (Stata Corp, College Station, TX, U.S.A.). Ultimately, 1,263 patients with breast cancer were found in a meta-analysis retrieved from a total that included 12 studies. Results of our meta-analysis suggested that BRMS1 protein in breast cancer tissues was significantly lower in comparison with normal breast tissues (odds ratio, OR = 0.08, 95% confidence interval (CI) = 0.04-0.15). The BRMS1 protein in metastatic breast cancer tissue was decreased than from that was found in non-metastatic breast cancer tissue (OR = 0.20, 95%CI = 0.13-0.29), and BRMS1 protein in tumor-node-metastasis (TNM) stages 1 and 2 was found to be higher than TNM stages 3 and 4 (OR = 4.62, 95%CI = 2.77-7.70). BRMS1 protein in all three major types of breast cancer was lower than that of control tissues respectively. We also found strong correlations between BRMS1 mRNA levels and TNM stage and tumor size. The results our meta-analysis showed that reduction in BRMS1 expression level was linked directly to clinico-pathological features of breast cancer significantly; therefore, suggesting the loss of expression or reduced levels of BRMS1 is potentially a strong indicator of the metastatic capacity of breast cancer with poor prognosis. (© 2017 The Author(s).) |
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| فهرسة مساهمة: | Keywords: BRMS1; Breast cancer; Clinico-pathological features; Meta-analysis; Metastasis; Prognosis |
| المشرفين على المادة: | 0 (BRMS1 protein, human) 0 (Biomarkers, Tumor) 0 (RNA, Messenger) 0 (Repressor Proteins) |
| تواريخ الأحداث: | Date Created: 20170524 Date Completed: 20180608 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5563535 |
| DOI: | 10.1042/BSR20170672 |
| PMID: | 28533425 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1573-4935 |
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| DOI: | 10.1042/BSR20170672 |