دورية أكاديمية
The Limiting-Pool Mechanism Fails to Control the Size of Multiple Organelles.
العنوان: | The Limiting-Pool Mechanism Fails to Control the Size of Multiple Organelles. |
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المؤلفون: | Mohapatra L; Department of Physics, Brandeis University, Waltham, MA 02454, USA. Electronic address: lishi87@brandeis.edu., Lagny TJ; Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, 75005 Paris, France; Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France., Harbage D; Department of Physics, Brandeis University, Waltham, MA 02454, USA., Jelenkovic PR; Department of Electrical Engineering, Columbia University, New York, NY 10027, USA., Kondev J; Department of Physics, Brandeis University, Waltham, MA 02454, USA. |
المصدر: | Cell systems [Cell Syst] 2017 May 24; Vol. 4 (5), pp. 559-567.e14. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101656080 Publication Model: Print Cited Medium: Print ISSN: 2405-4712 (Print) Linking ISSN: 24054712 NLM ISO Abbreviation: Cell Syst Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, [2015]- |
مواضيع طبية MeSH: | Cell Size*, Computational Biology/*methods , Organelles/*metabolism, Actin Cytoskeleton/chemistry ; Actins/analysis ; Biophysical Phenomena ; Computer Simulation ; Cytoskeleton/chemistry ; Models, Biological ; Systems Biology/methods |
مستخلص: | How the size of micrometer-scale cellular structures such as the mitotic spindle, cytoskeletal filaments, the nucleus, the nucleolus, and other non-membrane bound organelles is controlled despite a constant turnover of their constituent parts is a central problem in biology. Experiments have implicated the limiting-pool mechanism: structures grow by stochastic addition of molecular subunits from a finite pool until the rates of subunit addition and removal are balanced, producing a structure of well-defined size. Here, we consider these dynamics when multiple filamentous structures are assembled stochastically from a shared pool of subunits. Using analytical calculations and computer simulations, we show that robust size control can be achieved only when a single filament is assembled. When multiple filaments compete for monomers, filament lengths exhibit large fluctuations. These results extend to three-dimensional structures and reveal the physical limitations of the limiting-pool mechanism of size control when multiple organelles are assembled from a shared pool of subunits. (Copyright © 2017 Elsevier Inc. All rights reserved.) |
التعليقات: | Comment in: Cell Syst. 2017 May 24;4(5):480-482. (PMID: 28544879) |
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معلومات مُعتمدة: | United Kingdom Wellcome Trust; R13 GM085967 United States GM NIGMS NIH HHS; T32 EB009419 United States EB NIBIB NIH HHS |
فهرسة مساهمة: | Keywords: cytoskeleton filaments; limiting pool; master equation; organelle size; self-assembly; size control |
المشرفين على المادة: | 0 (Actins) |
تواريخ الأحداث: | Date Created: 20170526 Date Completed: 20190701 Latest Revision: 20190701 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5906859 |
DOI: | 10.1016/j.cels.2017.04.011 |
PMID: | 28544883 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2405-4712 |
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DOI: | 10.1016/j.cels.2017.04.011 |