دورية أكاديمية
أعرض في EDS

The Limiting-Pool Mechanism Fails to Control the Size of Multiple Organelles.

التفاصيل البيبلوغرافية
العنوان: The Limiting-Pool Mechanism Fails to Control the Size of Multiple Organelles.
المؤلفون: Mohapatra L; Department of Physics, Brandeis University, Waltham, MA 02454, USA. Electronic address: lishi87@brandeis.edu., Lagny TJ; Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, 75005 Paris, France; Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France., Harbage D; Department of Physics, Brandeis University, Waltham, MA 02454, USA., Jelenkovic PR; Department of Electrical Engineering, Columbia University, New York, NY 10027, USA., Kondev J; Department of Physics, Brandeis University, Waltham, MA 02454, USA.
المصدر: Cell systems [Cell Syst] 2017 May 24; Vol. 4 (5), pp. 559-567.e14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101656080 Publication Model: Print Cited Medium: Print ISSN: 2405-4712 (Print) Linking ISSN: 24054712 NLM ISO Abbreviation: Cell Syst Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2015]-
مواضيع طبية MeSH: Cell Size*, Computational Biology/*methods , Organelles/*metabolism, Actin Cytoskeleton/chemistry ; Actins/analysis ; Biophysical Phenomena ; Computer Simulation ; Cytoskeleton/chemistry ; Models, Biological ; Systems Biology/methods
مستخلص: How the size of micrometer-scale cellular structures such as the mitotic spindle, cytoskeletal filaments, the nucleus, the nucleolus, and other non-membrane bound organelles is controlled despite a constant turnover of their constituent parts is a central problem in biology. Experiments have implicated the limiting-pool mechanism: structures grow by stochastic addition of molecular subunits from a finite pool until the rates of subunit addition and removal are balanced, producing a structure of well-defined size. Here, we consider these dynamics when multiple filamentous structures are assembled stochastically from a shared pool of subunits. Using analytical calculations and computer simulations, we show that robust size control can be achieved only when a single filament is assembled. When multiple filaments compete for monomers, filament lengths exhibit large fluctuations. These results extend to three-dimensional structures and reveal the physical limitations of the limiting-pool mechanism of size control when multiple organelles are assembled from a shared pool of subunits.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Cell Syst. 2017 May 24;4(5):480-482. (PMID: 28544879)
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معلومات مُعتمدة: United Kingdom Wellcome Trust; R13 GM085967 United States GM NIGMS NIH HHS; T32 EB009419 United States EB NIBIB NIH HHS
فهرسة مساهمة: Keywords: cytoskeleton filaments; limiting pool; master equation; organelle size; self-assembly; size control
المشرفين على المادة: 0 (Actins)
تواريخ الأحداث: Date Created: 20170526 Date Completed: 20190701 Latest Revision: 20190701
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5906859
DOI: 10.1016/j.cels.2017.04.011
PMID: 28544883
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-4712
DOI:10.1016/j.cels.2017.04.011