دورية أكاديمية
Effect of Magnesium Supplementation on Plasma C-reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
| العنوان: | Effect of Magnesium Supplementation on Plasma C-reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. |
|---|---|
| المؤلفون: | Simental-Mendia LE; Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico., Sahebkar A; Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Rodriguez-Moran M; Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico., Zambrano-Galvan G; Laboratory of Molecular Stomatology, Faculty of Dentistry, Universidad Juarez de Estado de Durango, Durango, Mexico., Guerrero-Romero F; Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico. |
| المصدر: | Current pharmaceutical design [Curr Pharm Des] 2017; Vol. 23 (31), pp. 4678-4686. |
| نوع المنشور: | Journal Article; Meta-Analysis; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9602487 Publication Model: Print Cited Medium: Internet ISSN: 1873-4286 (Electronic) Linking ISSN: 13816128 NLM ISO Abbreviation: Curr Pharm Des Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers Original Publication: Schiphol, The Netherlands : Bentham Science Publishers, c1995- |
| مواضيع طبية MeSH: | Dietary Supplements*, C-Reactive Protein/*metabolism , Inflammation/*blood , Magnesium/*pharmacology, C-Reactive Protein/analysis ; Humans ; Inflammation/drug therapy ; Magnesium/administration & dosage ; Magnesium/therapeutic use ; Randomized Controlled Trials as Topic |
| مستخلص: | Background: Results of previous clinical trials evaluating the effect of magnesium supplementation on inflammatory markers are controversial. Objective: A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to evaluating the effect of oral magnesium supplementation on plasma C-reactive protein (CRP) concentrations. Method: PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched (from inception to August 09, 2016) to identify RCTs, evaluating the effect of magnesium on CRP levels. A random-effects model and a generic inverse variance method were used to compensate for the heterogeneity of studies. Publication bias, sensitivity analysis, and meta-regression assessments were conducted using standard methods. Results: Overall, the impact of magnesium supplementation on plasma concentrations of CRP was assessed in 11 studies. Magnesium treatment was not found to significantly affect plasma concentrations of CRP (WMD: -0.11 mg/L, 95% CI: -0.75, 0.52, p=0.727). When the analysis was stratified to compare subgroups of studies in populations with baseline plasma CRP values of ≤ 3 and > 3 mg/L, a significant reduction of CRP values was observed in the latter subgroup (WMD: -1.12 mg/L, 95% CI: -2.05, -0.18, p=0.019) but not in the former group (WMD: 0.61 mg/L, 95% CI: -0.10, 1.32, p=0.090). The difference between subgroups was statistically significant (p=0.004). Conclusion: Results of the present meta-analysis indicated that magnesium supplementation reduces CRP levels among individuals with inflammation (CRP levels > 3 mg/dL). This finding suggests that magnesium supplements may have a beneficial role as an adjuvant for the management of low-grade chronic systemic inflammation. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.) |
| فهرسة مساهمة: | Keywords: C-reactive protein; Magnesium; inflammation; meta-analysis; plasma concentrations; randomized controlled trials |
| المشرفين على المادة: | 9007-41-4 (C-Reactive Protein) I38ZP9992A (Magnesium) |
| تواريخ الأحداث: | Date Created: 20170527 Date Completed: 20180717 Latest Revision: 20181202 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2174/1381612823666170525153605 |
| PMID: | 28545353 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-4286 |
|---|---|
| DOI: | 10.2174/1381612823666170525153605 |