دورية أكاديمية
Evaluation of two strategies for the interpretation of tumour markers in pleural effusions.
| العنوان: | Evaluation of two strategies for the interpretation of tumour markers in pleural effusions. |
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| المؤلفون: | Trapé J; Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Dr Joan Soler 1-3, 08243, Manresa, Catalonia, Spain. jtrape@althaia.cat., Sant F; Department of Pathology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Franquesa J; Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Dr Joan Soler 1-3, 08243, Manresa, Catalonia, Spain., Montesinos J; Department of Oncology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Arnau A; Clinical Research Unit, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Sala M; Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Dr Joan Soler 1-3, 08243, Manresa, Catalonia, Spain., Bernadich O; Department of Pulmonary Diseases, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Martín E; Department of Pulmonary Diseases, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Perich D; Department of Pulmonary Diseases, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Pérez C; Department of Pulmonary Diseases, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Lopez J; Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Dr Joan Soler 1-3, 08243, Manresa, Catalonia, Spain., Ros S; Department of Pulmonary Diseases, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Esteve E; Department Internal Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Pérez R; Department Internal Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Aligué J; Department Internal Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Gurt G; Polytechnic School of University of Vic, Universitat Central de Catalunya, Vic, Catalonia, Spain., Catot S; Department of Oncology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Domenech M; Department of Oncology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Bosch J; Department of Medicine, Universitat Internacional de Catalunya, Sant Cugat, Catalonia, Spain., Badal JM; Department of Pathology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Bonet M; Department Internal Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain., Molina R; Laboratory of Biochemistry (Oncobiology Unit), Biomedical Diagnostic Center (CDB), Hospital Clinic, IDIBAPS, University of Barcelona, Catalonia, Spain., Ordeig J; Department Internal Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Catalonia, Spain. |
| المصدر: | Respiratory research [Respir Res] 2017 May 25; Vol. 18 (1), pp. 103. Date of Electronic Publication: 2017 May 25. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2001- : London : BioMed Central Ltd. Original Publication: London : Current Science Ltd., c2000- |
| مواضيع طبية MeSH: | Biomarkers, Tumor/*metabolism , Pleural Effusion, Malignant/*diagnosis , Pleural Effusion, Malignant/*metabolism, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Electrochemical Techniques/standards ; Female ; Humans ; Male ; Middle Aged ; Pleural Effusion/diagnosis ; Pleural Effusion/metabolism ; Young Adult |
| مستخلص: | Background: Pleural effusions present a diagnostic challenge. Approximately 20% are associated with cancer and some 50% require invasive procedures to perform diagnosis. Determination of tumour markers may help to identify patients with malignant effusions. Two strategies are used to obtain high specificity in the differential diagnosis of malignant pleural effusions: a) high cut-off, and b) fluid/serum (F/S) ratio and low cut-off. The aim of this study is to compare these two strategies and to establish whether the identification of possible false positives using benign biomarkers - ADA, CRP and % of polymorphonuclear cells - improves diagnostic accuracy. Methods: We studied 402 pleural effusions, 122 of them malignant. Benign biomarkers were determined in pleural fluid, and CEA, CA72-4, CA19-9 and CA15-3 in pleural fluid and serum. Results: Establishing a cut-off value for each TM for a specificity of 100%, a joint sensitivity of 66.5% was obtained. With the F/S strategy and low cut-off points, sensitivity was 77% and specificity 98.2%, Subclassifying cases with negative benign biomarkers, both strategies achieved a specificity of 100%; sensitivity was 69.9% for single determination and 80.6% for F/S ratio. Conclusions: The best interpretation of TM in the differential diagnosis of malignant pleural effusions is obtained using the F/S ratio in the group with negative benign biomarkers. |
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| فهرسة مساهمة: | Keywords: Cancer; Diagnostic; Pleural effusion; Tumour markers |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) |
| تواريخ الأحداث: | Date Created: 20170527 Date Completed: 20180319 Latest Revision: 20220316 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5445332 |
| DOI: | 10.1186/s12931-017-0582-1 |
| PMID: | 28545517 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1465-993X |
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| DOI: | 10.1186/s12931-017-0582-1 |