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Preliminary study of the safety and efficacy of medium-chain triglycerides for use as an intraocular tamponading agent in minipigs.

التفاصيل البيبلوغرافية
العنوان: Preliminary study of the safety and efficacy of medium-chain triglycerides for use as an intraocular tamponading agent in minipigs.
المؤلفون: Soler VJ; Unité de Rétine, Ophthalmology Department, Hôpital Pierre-Paul Riquet, Toulouse University Hospital, Place Baylac, TSA 40031, 31059, Toulouse Cedex 9, France. vincesoler@yahoo.fr.; Unité Différenciation Epithéliale et Autoimmunité Rhumatoïde, UMR 1056 Inserm - Université Toulouse III, Toulouse, France. vincesoler@yahoo.fr.; Université Toulouse III, F-31000, Toulouse, France. vincesoler@yahoo.fr., Laurent C; Université Toulouse III, F-31000, Toulouse, France.; Department of Pathology, Institut Universitaire du Cancer de Toulouse, Oncopole, Toulouse, France., Sakr F; Unité de Rétine, Ophthalmology Department, Hôpital Pierre-Paul Riquet, Toulouse University Hospital, Place Baylac, TSA 40031, 31059, Toulouse Cedex 9, France., Regnier A; Département des Sciences Cliniques, INP-Ecole Nationale Vétérinaire, 31076, Toulouse Cedex 3, France., Tricoire C; Unité Différenciation Epithéliale et Autoimmunité Rhumatoïde, UMR 1056 Inserm - Université Toulouse III, Toulouse, France.; Université Toulouse III, F-31000, Toulouse, France., Cases O; Institut de la Vision, INSERM U968, CNRS UMR7210, Université Pierre et Marie Curie UMRS968, 17 Rue Moreau, F-75012, Paris, France., Kozyraki R; Institut de la Vision, INSERM U968, CNRS UMR7210, Université Pierre et Marie Curie UMRS968, 17 Rue Moreau, F-75012, Paris, France., Douet JY; Département des Sciences Cliniques, INP-Ecole Nationale Vétérinaire, 31076, Toulouse Cedex 3, France., Pagot-Mathis V; Unité de Rétine, Ophthalmology Department, Hôpital Pierre-Paul Riquet, Toulouse University Hospital, Place Baylac, TSA 40031, 31059, Toulouse Cedex 9, France.
المصدر: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2017 Aug; Vol. 255 (8), pp. 1593-1604. Date of Electronic Publication: 2017 May 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8205248 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-702X (Electronic) Linking ISSN: 0721832X NLM ISO Abbreviation: Graefes Arch Clin Exp Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin ; New York : Springer-Verlag, c1982-
مواضيع طبية MeSH: Endotamponade/*methods , Retina/*surgery , Retinal Detachment/*surgery , Triglycerides/*administration & dosage , Vitrectomy/*methods, Animals ; Disease Models, Animal ; Electroretinography ; Male ; Microscopy, Electron ; Retina/physiopathology ; Retina/ultrastructure ; Retinal Detachment/diagnosis ; Retinal Detachment/physiopathology ; Swine ; Swine, Miniature ; Treatment Outcome ; Visual Acuity
مستخلص: Purpose: To date, only silicone oils and gases have the appropriate characteristics for use in vitreo-retinal surgery as vitreous substitutes with intraocular tamponading properties. This preliminary study evaluated the safety and efficacy of medium-chain triglycerides (MCTs) for use as a tamponading agent in minipigs.
Methods: In 15 minipigs, 15 right eyes underwent vitrectomies followed by injection of MCT tamponade (day 1). Two groups were defined. In Group A (ten eyes), the surgical procedure before MCT injection included induced rhegmatogenous retinal detachment (RRD), retina flattening, and retinopexy. In Group B (five eyes), MCT was injected without inducing RRD; in these eyes, MCT was removed on day 90. Pigs were sacrificed on day 45 (Group A) or 120 (Group B). Eyes were examined on days 1, 5, 15, and 45 in both groups and on days 90 and 120 in Group B. In Group B only, we performed bilateral electroretinography examinations on days 1 and 120, and histological examinations of MCTs and controlateral eyes were performed after sacrifice.
Results: In Group A eyes (n = 9; one eye was non-assessable), on day 45, the retina was flat in seven eyes and two RRD detachments were observed in insufficiently MCT-filled eyes. In Group B, electroretinography showed no significant differences between MCT eyes and controls on days 1 or 120. Histological analyses revealed no signs of retinal toxicity.
Conclusions: This study showed that MCT tamponade seems to be effective and safe; however, additional studies are needed before it becomes commonly used as a tamponading agent in humans.
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فهرسة مساهمة: Keywords: Electroretinography; Histology; Intraocular tamponade; Medium-chain triglycerides; Minipig; Retinal detachment; Safety
المشرفين على المادة: 0 (Triglycerides)
تواريخ الأحداث: Date Created: 20170527 Date Completed: 20171120 Latest Revision: 20181113
رمز التحديث: 20240628
DOI: 10.1007/s00417-017-3695-9
PMID: 28547316
قاعدة البيانات: MEDLINE
الوصف
تدمد:1435-702X
DOI:10.1007/s00417-017-3695-9