دورية أكاديمية
High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus.
| العنوان: | High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus. |
|---|---|
| المؤلفون: | Haddow AD, Nalca A, Rossi FD, Miller LJ, Wiley MR, Perez-Sautu U, Washington SC, Norris SL, Wollen-Roberts SE, Shamblin JD, Kimmel AE, Bloomfield HA, Valdez SM, Sprague TR, Principe LM, Bellanca SA, Cinkovich SS, Lugo-Roman L, Cazares LH, Pratt WD, Palacios GF, Bavari S, Pitt ML, Nasar F |
| المصدر: | Emerging infectious diseases [Emerg Infect Dis] 2017 Aug; Vol. 23 (8), pp. 1274-1281. Date of Electronic Publication: 2017 Aug 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995- |
| مواضيع طبية MeSH: | Macaca fascicularis* , Macaca mulatta*, Zika Virus/*physiology , Zika Virus Infection/*virology, Animals ; Female ; Male ; Vagina ; Virus Replication ; Virus Shedding ; Zika Virus Infection/transmission |
| مستخلص: | Unprotected sexual intercourse between persons residing in or traveling from regions with Zika virus transmission is a risk factor for infection. To model risk for infection after sexual intercourse, we inoculated rhesus and cynomolgus macaques with Zika virus by intravaginal or intrarectal routes. In macaques inoculated intravaginally, we detected viremia and virus RNA in 50% of macaques, followed by seroconversion. In macaques inoculated intrarectally, we detected viremia, virus RNA, or both, in 100% of both species, followed by seroconversion. The magnitude and duration of infectious virus in the blood of macaques suggest humans infected with Zika virus through sexual transmission will likely generate viremias sufficient to infect competent mosquito vectors. Our results indicate that transmission of Zika virus by sexual intercourse might serve as a virus maintenance mechanism in the absence of mosquito-to-human transmission and could increase the probability of establishment and spread of Zika virus in regions where this virus is not present. |
| References: | N Engl J Med. 2016 Jun 2;374(22):2195-8. (PMID: 27074370) Int J Infect Dis. 2016 Oct;51:128-132. (PMID: 27664930) Nature. 2016 Aug 25;536(7617):474-8. (PMID: 27355570) Science. 2016 Sep 9;353(6304):1129-32. (PMID: 27492477) Trans R Soc Trop Med Hyg. 1952 Sep;46(5):509-20. (PMID: 12995440) PLoS One. 2014 Mar 25;9(3):e92830. (PMID: 24667371) Lancet Infect Dis. 2016 Oct;16(10):1107. (PMID: 27676342) Clin Microbiol Rev. 2016 Jul;29(3):487-524. (PMID: 27029595) MMWR Morb Mortal Wkly Rep. 2016 Apr 15;65(14):372-4. (PMID: 27078057) Trans R Soc Trop Med Hyg. 1952 Sep;46(5):521-34. (PMID: 12995441) Curr Opin HIV AIDS. 2010 Jul;5(4):305-10. (PMID: 20543605) Bull World Health Organ. 2016 Dec 1;94(12 ):880-892. (PMID: 27994281) Nat Med. 2016 Dec;22(12 ):1448-1455. (PMID: 27694931) Lancet Infect Dis. 2016 Apr;16(4):405. (PMID: 26949027) Am J Trop Med Hyg. 1970 Jan;19(1):110-8. (PMID: 4984581) J Med Primatol. 2015 Oct;44(5):301-5. (PMID: 26054016) Cell Rep. 2016 Aug 9;16(6):1485-91. (PMID: 27481466) Euro Surveill. 2016 May 5;21(18):. (PMID: 27171034) Lancet Infect Dis. 2016 Dec;16(12 ):1356-1363. (PMID: 27641777) Bull World Health Organ. 1964;31:57-69. (PMID: 14230895) Emerg Infect Dis. 2016 Jul;22(7):1185-92. (PMID: 27070380) Lancet Infect Dis. 2009 Feb;9(2):118-29. (PMID: 19179227) MMWR Morb Mortal Wkly Rep. 2016 Sep 02;65(34):915-6. (PMID: 27585037) Lancet Infect Dis. 2016 Oct;16(10):1106-7. (PMID: 27676340) Travel Med Infect Dis. 2016 Jul-Aug;14 (4):313-30. (PMID: 27425793) Euro Surveill. 2016 Aug 11;21(32):. (PMID: 27542178) Nat Med. 2016 Nov;22(11):1256-1259. (PMID: 27618651) Emerg Infect Dis. 2011 May;17(5):880-2. (PMID: 21529401) J Gen Virol. 1989 Jan;70 ( Pt 1):37-43. (PMID: 2543738) Nat Commun. 2016 Jun 28;7:12204. (PMID: 27352279) PLoS Negl Trop Dis. 2012;6(2):e1477. (PMID: 22389730) J Med Primatol. 2010 Feb;39(1):41-9. (PMID: 19878432) Science. 2016 Oct 14;354(6309):237-240. (PMID: 27708058) EBioMedicine. 2016 Oct;12 :170-177. (PMID: 27693104) J Med Entomol. 1974 Aug;11(4):455-8. (PMID: 4423657) N Engl J Med. 2016 Apr 21;374(16):1552-63. (PMID: 27028561) PLoS Negl Trop Dis. 2016 Dec 2;10 (12 ):e0005168. (PMID: 27911897) MMWR Morb Mortal Wkly Rep. 2016 Mar 04;65(8):215-6. (PMID: 26937739) J Gen Virol. 1974 Apr;23(1):91-6. (PMID: 4833603) Emerg Infect Dis. 2015 Feb;21(2):359-61. (PMID: 25625872) Euro Surveill. 2016 Jun 9;21(23 ):. (PMID: 27311329) PLoS Negl Trop Dis. 2016 Oct 26;10 (10 ):e0005083. (PMID: 27783682) Am J Trop Med Hyg. 2009 Sep;81(3):457-62. (PMID: 19706915) Clin Microbiol Infect. 2017 May;23 (5):296-305. (PMID: 28062314) Am J Trop Med Hyg. 1969 May;18(3):411-5. (PMID: 4976739) PLoS Negl Trop Dis. 2014 Jan 09;8(1):e2636. (PMID: 24421913) Bull World Health Organ. 2016 Oct 1;94(10 ):711-711A. (PMID: 27843157) Trans R Soc Trop Med Hyg. 1956 May;50(3):238-42. (PMID: 13337908) Euro Surveill. 2016 Aug 11;21(32):. (PMID: 27541989) |
| فهرسة مساهمة: | Keywords: Zika virus; arbovirus; cynomolgus macaques; infection rates; intrarectal inoculation; intravaginal inoculation; macaques; mosquitoes; nonhuman primates; rhesus macaques; sexual transmission; vector-borne infections; viruses; zoonoses |
| تواريخ الأحداث: | Date Created: 20170527 Date Completed: 20180330 Latest Revision: 20220317 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5547779 |
| DOI: | 10.3201/eid2308.170036 |
| PMID: | 28548637 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1080-6059 |
|---|---|
| DOI: | 10.3201/eid2308.170036 |