دورية أكاديمية
High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus.
العنوان: | High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus. |
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المؤلفون: | Haddow AD, Nalca A, Rossi FD, Miller LJ, Wiley MR, Perez-Sautu U, Washington SC, Norris SL, Wollen-Roberts SE, Shamblin JD, Kimmel AE, Bloomfield HA, Valdez SM, Sprague TR, Principe LM, Bellanca SA, Cinkovich SS, Lugo-Roman L, Cazares LH, Pratt WD, Palacios GF, Bavari S, Pitt ML, Nasar F |
المصدر: | Emerging infectious diseases [Emerg Infect Dis] 2017 Aug; Vol. 23 (8), pp. 1274-1281. Date of Electronic Publication: 2017 Aug 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995- |
مواضيع طبية MeSH: | Macaca fascicularis* , Macaca mulatta*, Zika Virus/*physiology , Zika Virus Infection/*virology, Animals ; Female ; Male ; Vagina ; Virus Replication ; Virus Shedding ; Zika Virus Infection/transmission |
مستخلص: | Unprotected sexual intercourse between persons residing in or traveling from regions with Zika virus transmission is a risk factor for infection. To model risk for infection after sexual intercourse, we inoculated rhesus and cynomolgus macaques with Zika virus by intravaginal or intrarectal routes. In macaques inoculated intravaginally, we detected viremia and virus RNA in 50% of macaques, followed by seroconversion. In macaques inoculated intrarectally, we detected viremia, virus RNA, or both, in 100% of both species, followed by seroconversion. The magnitude and duration of infectious virus in the blood of macaques suggest humans infected with Zika virus through sexual transmission will likely generate viremias sufficient to infect competent mosquito vectors. Our results indicate that transmission of Zika virus by sexual intercourse might serve as a virus maintenance mechanism in the absence of mosquito-to-human transmission and could increase the probability of establishment and spread of Zika virus in regions where this virus is not present. |
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فهرسة مساهمة: | Keywords: Zika virus; arbovirus; cynomolgus macaques; infection rates; intrarectal inoculation; intravaginal inoculation; macaques; mosquitoes; nonhuman primates; rhesus macaques; sexual transmission; vector-borne infections; viruses; zoonoses |
تواريخ الأحداث: | Date Created: 20170527 Date Completed: 20180330 Latest Revision: 20220317 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC5547779 |
DOI: | 10.3201/eid2308.170036 |
PMID: | 28548637 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1080-6059 |
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DOI: | 10.3201/eid2308.170036 |