دورية أكاديمية
Maternal Magnesium Restriction Elevates Glucocorticoid Stress and Inflammation in the Placenta and Fetus of WNIN Rat Dams.
| العنوان: | Maternal Magnesium Restriction Elevates Glucocorticoid Stress and Inflammation in the Placenta and Fetus of WNIN Rat Dams. |
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| المؤلفون: | Thomas AE; Division of Endocrinology and Metabolism, National Institute of Nutrition (ICMR), Jamai Osmania, Hyderabad, Telangana, 500007, India., Inagadapa PJN; Division of Endocrinology and Metabolism, National Institute of Nutrition (ICMR), Jamai Osmania, Hyderabad, Telangana, 500007, India., Jeyapal S; Division of Endocrinology and Metabolism, National Institute of Nutrition (ICMR), Jamai Osmania, Hyderabad, Telangana, 500007, India., Merugu NM; Molecular Genetics, National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Hyderabad, India., Kalashikam RR; Molecular Genetics, National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Hyderabad, India. rkrajender@yahoo.com., Manchala R; Division of Endocrinology and Metabolism, National Institute of Nutrition (ICMR), Jamai Osmania, Hyderabad, Telangana, 500007, India. mraghunath55@yahoo.com. |
| المصدر: | Biological trace element research [Biol Trace Elem Res] 2018 Feb; Vol. 181 (2), pp. 281-287. Date of Electronic Publication: 2017 May 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London, Clifton, N. J.] Humana Press. |
| مواضيع طبية MeSH: | Fetus/*drug effects , Glucocorticoids/*antagonists & inhibitors , Inflammation/*drug therapy , Magnesium/*pharmacology , Placenta/*drug effects , Stress, Physiological/*drug effects, Animal Feed ; Animals ; Animals, Newborn ; Diet ; Female ; Fetus/metabolism ; Glucocorticoids/metabolism ; Magnesium/administration & dosage ; Placenta/metabolism ; Pregnancy ; Rats ; Rats, Inbred Strains |
| مستخلص: | Magnesium plays a major role in many vital functions in the body. We reported earlier that maternal magnesium restriction altered body composition, fat metabolism, and insulin resistance in WNIN rat offspring and was associated with increased glucocorticoid stress in the offspring in their later life. We hypothesize that increased glucocorticoid stress and inflammation which originate in Mg restricted rat dams is transmitted through placenta to the fetus and underlie the metabolic disturbances in the later life of the offspring. Female weanling WNIN rats received ad libitum, a control diet (MgC) or the same with 62% restriction of Mg (MgR) for 3 months, and their plasma magnesium, inflammatory cytokines, and corticosterone were determined (n = 6 per group) before mating. Following mating with control males, placentae, and fetuses were collected on gestational day 15 (GD 15) from MgC and MgR dams (eight dams from each group and three samples from each dam) and used to determine the levels of inflammatory cytokines, corticosterone, and expression of relevant genes. MgR placentae and fetuses had higher (than MgC) levels of corticosterone and proinflammatory cytokines. Expression of Hsd11b1 was increased (sixfold, p < 0.05), while that of Hsd11b2 was decreased (0.4-fold, p < 0.05) in MgR (than MgC) placenta, whereas expression of Hsd11b1was increased (3.4-fold, p < 0.05) in MgR fetus. Chronic dietary magnesium restriction in WNIN female rats increased their levels of corticosterone, leptin, and proinflammatory cytokines which appeared to be transmitted through placenta to the fetus and could thus be associated with increased stress, altered body composition, fat metabolism, and insulin resistance in the later life of the offspring. |
| معلومات مُعتمدة: | BT/PR-11409/FNS/20/396/2008 Department of Biotechnology , Ministry of Science and Technology |
| فهرسة مساهمة: | Keywords: Adult disease; Fetal programming; Glucocorticoid stress; Inflammation; Magnesium |
| المشرفين على المادة: | 0 (Glucocorticoids) I38ZP9992A (Magnesium) |
| تواريخ الأحداث: | Date Created: 20170529 Date Completed: 20180810 Latest Revision: 20180810 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s12011-017-1058-3 |
| PMID: | 28551889 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1559-0720 |
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| DOI: | 10.1007/s12011-017-1058-3 |