دورية أكاديمية
أعرض في EDS

Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis.

التفاصيل البيبلوغرافية
العنوان: Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis.
المؤلفون: Amine MM; Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia., Mohamed B; Faculty of Medicine, Habib Bourguiba Hospital, Sfax, Tunisia., Mourad H; Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia., Majed H; Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia., Slim C; Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia., Mehdi B; Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia., Hela M; Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia., Nouri R; Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia., Rim K; Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia., Tahya B; Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia., Nabil MM; Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia.
المصدر: Current urology [Curr Urol] 2017 Apr; Vol. 10 (1), pp. 15-25. Date of Electronic Publication: 2017 Mar 30.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101471188 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1661-7649 (Print) Linking ISSN: 16617649 NLM ISO Abbreviation: Curr Urol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2021- : [Hagerstown, MD] : Wolters Kluwer Health, Inc.
Original Publication: Basel, Switzerland : Karger, c2007-
مستخلص: Purpose: The purpose of this study is to study the main epidemiological, clinical, para clinical, pathological, therapeutic, and evolutionary features of patients with testicular neuroendocrine tumors (TNET).
Materials and Methods: Nine case series and sixteen case reports were identified by searching PubMed database and qualified for inclusion in this study. We added the data of one case treated in the department of urology in Habib Bourguiba Hospital in Sfax, to the published cases.
Results: A total of 132 cases were collected. Median age at diagnosis was 39 years old (range 10- 83 years). The most common presenting symptom was either a testicular mass or a swelling in 38.46% of cases. Carcinoid syndrome was documented in 10.60% of patients. The clinical examination revealed a palpable mass in 44.70% of patients. This mass was painless and firm in most cases. Serum tumor markers (β-gonadotrophine chorionique humaine, α-feto protein, and lactate dehydrogenase) were within normal limits in all patients except in one case. Most testicular neuroendocrine tumors (76.52%) were primary and pure. The tumors were positive for chromogranin (100%), synaptophysin (100%) and cytokeratin (93.10%). Metastases were detected at time of diagnosis in eight cases (6.06%). The main treatment was radical orchiectomy performed in 127 patients (96.21%). The 5-year overall survival rate was 78.70% and the 5-year specific survival rate was 84.30%.
Conclusion: The diagnosis of testicular carcinoids is based on the immunohistochemistry study. The treatment of choice for these tumors is radical orchiectomy. Somatostatin analogues were reported to be effective in patients with carcinoid syndrome.
References: Can Urol Assoc J. 2013 Sep-Oct;7(9-10):E614-7. (PMID: 24069109)
Int J Urol. 2005 Mar;12(3):328-31. (PMID: 15828968)
Case Rep Pathol. 2013;2013:709352. (PMID: 24171129)
Cancer. 1993 Sep 1;72(5):1726-32. (PMID: 7688660)
Gastroenterol Clin Biol. 2010 Mar;34(3):213-7. (PMID: 19864098)
Case Rep Oncol. 2012 Jan;5(1):43-6. (PMID: 22379476)
J Androl. 2004 May-Jun;25(3):338-9. (PMID: 15064309)
Int J Clin Exp Pathol. 2014 Mar 15;7(4):1771-6. (PMID: 24817977)
Urology. 2005 Mar;65(3):591. (PMID: 15780387)
Oncologist. 2012;17(6):747-55. (PMID: 22628056)
Oncologist. 2005 Feb;10(2):123-31. (PMID: 15709214)
J Clin Oncol. 2008 Jun 20;26(18):3063-72. (PMID: 18565894)
Urology. 2001 Mar;57(3):554-5. (PMID: 11248641)
J Korean Med Sci. 1999 Feb;14(1):57-62. (PMID: 10102525)
Best Pract Res Clin Endocrinol Metab. 2005 Jun;19(2):265-76. (PMID: 15763700)
Am J Surg Pathol. 2010 Apr;34(4):519-24. (PMID: 20351489)
J Clin Pathol. 2005 Dec;58(12):1331-3. (PMID: 16311359)
Arch Ital Urol Androl. 2014 Sep 30;86(3):231-2. (PMID: 25308595)
Int Urol Nephrol. 2006;38(3-4):625-8. (PMID: 17115244)
Ann Saudi Med. 1997 Mar;17(2):223-5. (PMID: 17377435)
Indian J Urol. 2015 Jan-Mar;31(1):65-7. (PMID: 25624579)
Case Rep Urol. 2015;2015:687482. (PMID: 25763289)
Clin Cancer Res. 2008 Mar 1;14(5):1393-6. (PMID: 18316560)
Pathol Int. 2003 Oct;53(10):680-5. (PMID: 14516318)
J Pediatr Surg. 2005 Nov;40(11):e19-21. (PMID: 16291134)
Ann Diagn Pathol. 2004 Apr;8(2):102-7. (PMID: 15060889)
Prog Urol. 2008 Nov;18 Suppl 7:S196-201. (PMID: 19070791)
Int J Urol. 2004 Nov;11(11):1041-3. (PMID: 15509216)
Can Urol Assoc J. 2014 Mar;8(3-4):E245-8. (PMID: 24839491)
Urology. 2005 Jan;65(1):174. (PMID: 15667892)
J Pak Med Assoc. 2005 Dec;55(12):561-3. (PMID: 16438281)
Am J Clin Pathol. 2001 Jun;115 Suppl:S94-112. (PMID: 11993694)
Ulster Med J. 2011 May;80(2):79-81. (PMID: 22347748)
Eur Respir J. 2001 Dec;18(6):1059-68. (PMID: 11829087)
Lancet Oncol. 2006 Sep;7(9):728-34. (PMID: 16945767)
J Nucl Med. 2008 Apr;49(4):573-86. (PMID: 18344441)
Int J Urol. 2001 Sep;8(9):522-4. (PMID: 11683977)
Am J Clin Pathol. 2003 Aug;120(2):182-7. (PMID: 12931547)
Urol Radiol. 1991;12(4):203-5. (PMID: 2042272)
Ann Oncol. 2001;12 Suppl 2:S111-4. (PMID: 11762335)
J Clin Oncol. 2010 Nov 1;28(31):e637-9. (PMID: 20855827)
J Urol. 1988 Jan;139(1):132-3. (PMID: 3275794)
BJU Int. 1999 Jan;83(1):153-4. (PMID: 10233475)
Urol Ann. 2014 Apr;6(2):173-5. (PMID: 24833836)
J Urol. 2006 Dec;176(6 Pt 1):2359-66. (PMID: 17085102)
Case Rep Oncol. 2014 Dec 04;7(3):815-8. (PMID: 25580103)
Prog Urol. 2003 Nov;13(5):969-84. (PMID: 14763392)
Ann Pathol. 2008 Sep;28(4):338-40. (PMID: 18928879)
J Ultrasound Med. 2006 Mar;25(3):413-6. (PMID: 16495507)
BJU Int. 2008 May;101(9):1101-5. (PMID: 18190641)
Chang Gung Med J. 2002 Oct;25(10):695-9. (PMID: 12518782)
Clin Gastroenterol Hepatol. 2006 May;4(5):526-47. (PMID: 16630755)
Prog Urol. 1995 Apr;5(2):274-5. (PMID: 7719374)
فهرسة مساهمة: Keywords: Meta-analysis; Neuroendocrine tumors; Testicular cancer
تواريخ الأحداث: Date Created: 20170601 Latest Revision: 20210612
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5436018
DOI: 10.1159/000447146
PMID: 28559773
قاعدة البيانات: MEDLINE
الوصف
تدمد:1661-7649
DOI:10.1159/000447146