دورية أكاديمية
Immunological and genotoxic effects of occupational exposure to α-cypermethrin pesticide.
| العنوان: | Immunological and genotoxic effects of occupational exposure to α-cypermethrin pesticide. |
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| المؤلفون: | El Okda ES; Ain Shams University, Cairo, Egypt (Faculty of Medicine, Community, Environmental and Occupational Medicine Department). Okda_82002@yahoo.com., Abdel-Hamid MA; Ain Shams University, Cairo, Egypt (Faculty of Medicine, Community, Environmental and Occupational Medicine Department). m_zahry@med.asu.edu.eg., Hamdy AM; VACSERA, Cairo, Egypt (Therapeutic Fluid Line). |
| المصدر: | International journal of occupational medicine and environmental health [Int J Occup Med Environ Health] 2017 Jun 19; Vol. 30 (4), pp. 603-615. Date of Electronic Publication: 2017 Jun 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nofer Institute of Occupational Medicine Country of Publication: Poland NLM ID: 9437093 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1896-494X (Electronic) Linking ISSN: 12321087 NLM ISO Abbreviation: Int J Occup Med Environ Health Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Lodz : Nofer Institute of Occupational Medicine Original Publication: Lodz : Nofer Institute of Occupational Medicine ; Polish Association of Occupational Medicine, [1994- |
| مواضيع طبية MeSH: | Occupational Exposure*, Insecticides/*poisoning , Pyrethrins/*poisoning, Adult ; Air Pollutants, Occupational/analysis ; Antioxidants/analysis ; CD4-CD8 Ratio ; Chemical Industry ; Cross-Sectional Studies ; Egypt/epidemiology ; Female ; Genes, p53 ; Humans ; Male ; Middle Aged ; Mutation ; Oxidative Stress/drug effects |
| مستخلص: | Objectives: The aim of this work has been to find out the occupational oxidative stress, immunological and genotoxic health hazards among α-cypermethrin (CYP) pesticide-exposed workers. Material and Methods: A cross-sectional study was performed including 200 workers divided into 3 groups according to the level of exposure: highly exposed group (50 workers), moderately exposed group (50 workers) and unexposed group (100 workers). All workers were subjected to detailed laboratory investigation for gene P53 mutations, immunological parameters as a cluster of differentiation into 3 percentage (CD3%), CD4% and CD8% in addition to peripheral blood total leukocytic and platelet counts that were measured. Spectrophotometer technique was used for detection of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione peroxidase (GPx). Air samples were collected with a High Volume Small Surface Sampler for measurement of α-cypermethrin level. Results: A highly exposed group to the α-cypermethrin had lower CD4/CD8 as compared to an unexposed group with statistically significant difference. As regards gene mutation, exons 5a and 6 were more frequent among the highly exposed group as compared to no mutation among moderately exposed and unexposed groups with significant difference. As regards antioxidants; SOD, CAT, GSH and GPx were higher among the unexposed group as compared to the highly and moderately exposed group with statistically significant difference. Significant negative correlation was found between working years and antioxidant parameters. Conclusions: Repeated exposure to α-CYP may lead to gene mutations, immunological disturbances and oxidative stress. Strict safety precautions are required not only for workers but also for public users. Int J Occup Med Environ Health 2017;30(4):603-615. (This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.) |
| فهرسة مساهمة: | Keywords: P53; cypermethrin; genotoxic; immunological; oxidative stress; pyrethroids |
| المشرفين على المادة: | 0 (Air Pollutants, Occupational) 0 (Antioxidants) 0 (Insecticides) 0 (Pyrethrins) 1TR49121NP (cypermethrin) |
| تواريخ الأحداث: | Date Created: 20170607 Date Completed: 20180312 Latest Revision: 20180312 |
| رمز التحديث: | 20231215 |
| DOI: | 10.13075/ijomeh.1896.00810 |
| PMID: | 28584332 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1896-494X |
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| DOI: | 10.13075/ijomeh.1896.00810 |