دورية أكاديمية
أعرض في EDS

Efficacy and Safety of Manual Partial Red Cell Exchange in the Management of Severe Complications of Sickle Cell Disease in a Developing Country.

التفاصيل البيبلوغرافية
العنوان: Efficacy and Safety of Manual Partial Red Cell Exchange in the Management of Severe Complications of Sickle Cell Disease in a Developing Country.
المؤلفون: Faye BF; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal., Sow D; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal., Seck M; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal., Dieng N; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal., Toure SA; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal., Gadji M; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal., Senghor AB; Centre National de Transfusion Sanguine, BP 5002, Dakar, Senegal., Gueye YB; Centre National de Transfusion Sanguine, BP 5002, Dakar, Senegal., Sy D; Centre National de Transfusion Sanguine, BP 5002, Dakar, Senegal., Sall A; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal., Dieye TN; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal., Toure AO; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal., Diop S; Hematology, Cheikh Anta Diop University, BP 5005, Dakar, Senegal.
المصدر: Advances in hematology [Adv Hematol] 2017; Vol. 2017, pp. 3518402. Date of Electronic Publication: 2017 May 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101504271 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1687-9104 (Print) NLM ISO Abbreviation: Adv Hematol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Corp.
مستخلص: Introduction: The realization of red cell exchange (RCE) in Africa faces the lack of blood, transfusion safety, and equipment. We evaluated its efficacy and safety in severe complications of sickle cell disease.
Patients and Method: Manual partial RCE was performed among sickle cell patients who had severe complications. Efficacy was evaluated by clinical evolution, blood count, and electrophoresis of hemoglobin. Safety was evaluated on adverse effects, infections, and alloimmunization.
Results: We performed 166 partial RCE among 44 patients including 41 homozygous (SS) and 2 heterozygous composites SC and 1 S/ β 0-thalassemia. The mean age was 27.9 years. The sex ratio was 1.58. The regression of symptoms was complete in 100% of persistent vasoocclusive crisis and acute chest syndrome, 56.7% of intermittent priapism, and 30% of stroke. It was partial in 100% of leg ulcers and null in acute priapism. The mean variations of hemoglobin and hematocrit rate after one procedure were, respectively, +1.4 g/dL and +4.4%. That of hemoglobin S after 2 consecutive RCE was -60%. Neither alloimmunization nor viral seroconversion was observed.
Conclusion: This work shows the feasibility of manual partial RCE in a low-resource setting and its efficacy and safety during complications of SCD outside of acute priapism.
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تواريخ الأحداث: Date Created: 20170607 Latest Revision: 20200929
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5443989
DOI: 10.1155/2017/3518402
PMID: 28584527
قاعدة البيانات: MEDLINE
الوصف
تدمد:1687-9104
DOI:10.1155/2017/3518402