دورية أكاديمية
Effects of repeated abobotulinumtoxinA injections in upper limb spasticity.
العنوان: | Effects of repeated abobotulinumtoxinA injections in upper limb spasticity. |
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المؤلفون: | Gracies JM; EA 7377 BIOTN, Université Paris-Est Créteil, Service de Rééducation Neurolocomotrice, Hôpitaux Universitaires Henri Mondor, 51, avenue du Maréchal De Lattre De Tassigny, 94010, Créteil, France., O'Dell M; Department of Rehabilitation Medicine, Weill Cornell Medicine, Baker Pavilion, New York, New York, USA., Vecchio M; Department of U.O. Physical Medicine and Rehabilitation, Policlinico Vittorio Emanuele University Hospital, Catania, Italy., Hedera P; Department of Neurology, Division of Movement Disorders, Vanderbilt University, Nashville, Tennessee, USA., Kocer S; Centre de Rééducation Hôpital du Jura, Porrentruy, Switzerland., Rudzinska-Bar M; Department of Neurology, Faculty of Medicine, Medical University of Silesia, Katowice, Poland., Rubin B; Design Neuroscience Center, Doral, Florida, USA., Timerbaeva SL; Research Center of Neurology, Moscow, Russia., Lusakowska A; Department of Neurology, Medical University of Warsaw, Poland., Boyer FC; EA 3797, Unités de Médecine Physique et de Réadaptation, Hôpital Universitaire Sébastopol, Champagne Ardenne, France., Grandoulier AS; Ipsen Innovation, Les Ulis, France., Vilain C; Ipsen Innovation, Les Ulis, France., Picaut P; Ipsen Innovation, Les Ulis, France. |
مؤلفون مشاركون: | International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group |
المصدر: | Muscle & nerve [Muscle Nerve] 2018 Feb; Vol. 57 (2), pp. 245-254. Date of Electronic Publication: 2017 Aug 13. |
نوع المنشور: | Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 7803146 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4598 (Electronic) Linking ISSN: 0148639X NLM ISO Abbreviation: Muscle Nerve Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2005-> : Hoboken, NJ : John Wiley & Sons Original Publication: New York, NY : John Wiley & Sons |
مواضيع طبية MeSH: | Botulinum Toxins, Type A/*therapeutic use , Muscle Spasticity/*drug therapy , Neuromuscular Agents/*therapeutic use , Upper Extremity/*physiopathology, Adult ; Aged ; Botulinum Toxins, Type A/administration & dosage ; Botulinum Toxins, Type A/adverse effects ; Disability Evaluation ; Double-Blind Method ; Elbow/physiopathology ; Female ; Fingers/physiopathology ; Humans ; Injections, Intramuscular ; Male ; Middle Aged ; Muscle Spasticity/physiopathology ; Muscle Tonus/drug effects ; Neuromuscular Agents/administration & dosage ; Neuromuscular Agents/adverse effects ; Range of Motion, Articular/drug effects ; Treatment Outcome ; Wrist/physiopathology |
مستخلص: | Introduction: The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods: Patients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500-U dose included 500-U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment-emergent adverse events (TEAEs), muscle tone, passive and active range of motion (X Results: The incidence of TEAEs decreased across cycles. Muscle tone reduction and X Discussion: A favorable safety profile and continuous improvements in active movements and perceived and active function were associated with repeated abobotulinumtoxinA injections in upper limb muscles. Muscle Nerve 57: 245-254, 2018. (© 2017 The Authors Muscle & Nerve Published by Wiley Periodicals, Inc.) |
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فهرسة مساهمة: | Keywords: active function; botulinum toxin; open label; stroke; traumatic brain injury; upper limb spasticity |
المشرفين على المادة: | 0 (Neuromuscular Agents) EC 3.4.24.69 (Botulinum Toxins, Type A) EC 3.4.24.69 (abobotulinumtoxinA) |
تواريخ الأحداث: | Date Created: 20170608 Date Completed: 20190128 Latest Revision: 20190128 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5811783 |
DOI: | 10.1002/mus.25721 |
PMID: | 28590525 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1097-4598 |
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DOI: | 10.1002/mus.25721 |