دورية أكاديمية
Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging.
العنوان: | Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging. |
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المؤلفون: | Miura M; Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ami, Japan. m-miura@tokyo-med.ac.jp.; Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. m-miura@tokyo-med.ac.jp., Makita S; Computational Optics Group, University of Tsukuba, Tsukuba, Japan., Sugiyama S; Computational Optics Group, University of Tsukuba, Tsukuba, Japan.; Tomey Corporation, Nagoya, Aichi, Japan., Hong YJ; Computational Optics Group, University of Tsukuba, Tsukuba, Japan., Yasuno Y; Computational Optics Group, University of Tsukuba, Tsukuba, Japan., Elsner AE; School of Optometry, Indiana University, Bloomington, IN, USA., Tamiya S; Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA., Tsukahara R; Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ami, Japan.; Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan., Iwasaki T; Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ami, Japan.; Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan., Goto H; Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. |
المصدر: | Scientific reports [Sci Rep] 2017 Jun 09; Vol. 7 (1), pp. 3150. Date of Electronic Publication: 2017 Jun 09. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Epithelial Cells/*pathology , Macular Degeneration/*diagnostic imaging , Retinal Detachment/*diagnostic imaging , Retinal Drusen/*diagnostic imaging , Retinal Pigment Epithelium/*diagnostic imaging , Scanning Laser Polarimetry/*methods, Aged ; Aged, 80 and over ; Cell Movement ; Disease Progression ; Female ; Humans ; Macular Degeneration/classification ; Macular Degeneration/pathology ; Male ; Middle Aged ; Ophthalmoscopy/methods ; Optical Imaging/methods ; Prospective Studies ; Retinal Detachment/classification ; Retinal Detachment/pathology ; Retinal Drusen/classification ; Retinal Drusen/pathology ; Retinal Pigment Epithelium/pathology ; Scanning Laser Polarimetry/instrumentation ; Tomography, Optical Coherence/methods |
مستخلص: | The purpose of the present study was to evaluate the intraretinal migration of the retinal pigment epithelium (RPE) cells in age-related macular degeneration (AMD) using polarimetry. We evaluated 155 eyes at various AMD stages. Depolarized light images were computed using a polarization-sensitive scanning laser ophthalmoscope (PS-SLO), and the degree of polarization uniformity was calculated using polarization-sensitive optical coherence tomography (OCT). Each polarimetry image was compared with the corresponding autofluorescence (AF) images at 488 nm (SW-AF) and at 787 nm (NIR-AF). Intraretinal RPE migration was defined by the presence of depolarization at intraretinal hyperreflective foci on PS-SLO and PS-OCT images, and by the presence of hyper-AF on both NIR-AF and SW-AF images. RPE migration was detected in 52 of 155 eyes (33.5%) and was observed in drusenoid pigment epithelial detachment (PED) and serous PED with significantly higher frequencies than in other groups (P = 0.015). The volume of the migrated RPE cluster in serous PED was significantly correlated with the volume of the PED (R 2 = 0.26; P = 0.011). Overall, our results showed that intraretinal RPE migrations occurred in various AMD stages, and that they occurred more commonly in eyes with serous and drusenoid PED. |
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معلومات مُعتمدة: | R41 EY026105 United States EY NEI NIH HHS; R44 EY024186 United States EY NEI NIH HHS |
تواريخ الأحداث: | Date Created: 20170611 Date Completed: 20181228 Latest Revision: 20201120 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5466639 |
DOI: | 10.1038/s41598-017-03529-8 |
PMID: | 28600515 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-017-03529-8 |