دورية أكاديمية
Comparison of the Tastes of L-Alanine and Monosodium Glutamate in C57BL/6J Wild Type and T1r3 Knockout Mice.
| العنوان: | Comparison of the Tastes of L-Alanine and Monosodium Glutamate in C57BL/6J Wild Type and T1r3 Knockout Mice. |
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| المؤلفون: | Eddy MC; Department of Biology and Vermont Chemical Senses Group, University of Vermont,109 Carrigan Drive, Burlington, VT 05405,USA., Eschle BK; Department of Biology and Vermont Chemical Senses Group, University of Vermont,109 Carrigan Drive, Burlington, VT 05405,USA., Delay ER; Department of Biology and Vermont Chemical Senses Group, University of Vermont,109 Carrigan Drive, Burlington, VT 05405,USA. |
| المصدر: | Chemical senses [Chem Senses] 2017 Sep 01; Vol. 42 (7), pp. 563-573. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8217190 Publication Model: Print Cited Medium: Internet ISSN: 1464-3553 (Electronic) Linking ISSN: 0379864X NLM ISO Abbreviation: Chem Senses Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Oxford University Press Original Publication: [London : IRL Press, c1980- |
| مواضيع طبية MeSH: | Alanine/*pharmacology , Sodium Glutamate/*pharmacology , Taste/*drug effects, Animals ; Discriminant Analysis ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, G-Protein-Coupled/deficiency ; Receptors, G-Protein-Coupled/genetics ; Taste Threshold/drug effects |
| مستخلص: | Previous research showed that L-alanine and monosodium L-glutamate elicit similar taste sensations in rats. This study reports the results of behavioral experiments designed to compare the taste capacity of C57BL/6J wild type and T1r3- mice for these 2 amino acids. In conditioned taste aversion (CTA) experiments, wild-type mice exhibited greater sensitivity than knockout mice for both L-amino acids, although knockout mice were clearly able to detect both amino acids at 50 mM and higher concentrations. Generalization of CTA between L-alanine and L-glutamate was bidirectionally equivalent for both mouse genotypes, indicating that both substances elicited similar tastes in both genotypes. This was verified by the discrimination experiments in which both mouse genotypes performed at or near chance levels at 75 and 150 mM. Above 150 mM, discrimination performance improved, suggesting the taste qualities of the 2 L-amino acids are not identical. No differences between knockout and wild-type mice in discrimination ability were detected. These results indicate that while the T1r3 receptor is important for tasting L-alanine and L-glutamate, other receptors are also important for tasting these amino acids. (© The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: animal psychophysics; condition taste aversion; discrimination; taste receptor; umami |
| المشرفين على المادة: | 0 (Receptors, G-Protein-Coupled) 0 (taste receptors, type 1) OF5P57N2ZX (Alanine) W81N5U6R6U (Sodium Glutamate) |
| تواريخ الأحداث: | Date Created: 20170613 Date Completed: 20170920 Latest Revision: 20170920 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/chemse/bjx037 |
| PMID: | 28605507 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3553 |
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| DOI: | 10.1093/chemse/bjx037 |