دورية أكاديمية
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.
| العنوان: | Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins. |
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| المؤلفون: | Matthews AL; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K., Szyroka J; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K., Collier R; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K., Noy PJ; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K., Tomlinson MG; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K. m.g.tomlinson@bham.ac.uk. |
| المصدر: | Biochemical Society transactions [Biochem Soc Trans] 2017 Jun 15; Vol. 45 (3), pp. 719-730. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Portland Press On The Behalf Of The Biochemical Society |
| مواضيع طبية MeSH: | ADAM10 Protein/*metabolism , Tetraspanins/*metabolism, Animals ; Humans ; Protein Conformation ; Protein Transport ; Substrate Specificity |
| مستخلص: | A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed transmembrane protein which is essential for embryonic development through activation of Notch proteins. ADAM10 regulates over 40 other transmembrane proteins and acts as a 'molecular scissor' by removing their extracellular regions. ADAM10 is also a receptor for α-toxin, a major virulence factor of Staphylococcus aureus Owing to the importance of its substrates, ADAM10 is a potential therapeutic target for cancer, neurodegenerative diseases such as Alzheimer's and prion diseases, bacterial infection and inflammatory diseases such as heart attack, stroke and asthma. However, targetting ADAM10 is likely to result in toxic side effects. The tetraspanins are a superfamily of 33 four-transmembrane proteins in mammals which interact with and regulate specific partner proteins within membrane nanodomains. Tetraspanins appear to have a cone-shaped structure with a cholesterol-binding cavity, which may enable tetraspanins to undergo cholesterol-regulated conformational change. An emerging paradigm for tetraspanin function is the regulation of ADAM10 by the TspanC8 subgroup of tetraspanins, namely Tspan5, 10, 14, 15, 17 and 33. This review will describe how TspanC8s are required for ADAM10 trafficking from the endoplasmic reticulum and its enzymatic maturation. Moreover, different TspanC8s localise ADAM10 to different subcellular localisations and may cause ADAM10 to adopt distinct conformations and cleavage of distinct substrates. We propose that ADAM10 should now be regarded as six different scissor proteins depending on the interacting TspanC8. Therapeutic targetting of specific TspanC8/ADAM10 complexes could allow ADAM10 targetting in a cell type- or substrate-specific manner, to treat certain diseases while minimising toxicity. (© 2017 The Author(s).) |
| References: | Mol Cell Biol. 2006 Oct;26(20):7707-18. (PMID: 16908530) Hum Mol Genet. 2002 Oct 1;11(21):2615-24. (PMID: 12354787) Mol Syst Biol. 2011 Oct 11;7:539. (PMID: 21988835) J Clin Invest. 2010 Apr;120(4):1265-74. (PMID: 20237408) Elife. 2015 Feb 05;4:null. (PMID: 25654651) J Immunol. 2007 Jun 15;178(12 ):8064-72. (PMID: 17548644) Development. 2012 Oct;139(20):3693-709. (PMID: 22991436) J Biol Chem. 2015 May 8;290(19):12135-46. (PMID: 25795784) Nat Rev Immunol. 2013 Sep;13(9):649-65. (PMID: 23969736) J Proteome Res. 2011 Jan 7;10(1):17-33. (PMID: 20849079) Blood. 2004 Oct 15;104(8):2217-23. (PMID: 15265795) J Biol Chem. 2015 Jul 10;290(28):17041-54. (PMID: 25925953) Cell. 2016 Nov 3;167(4):1041-1051.e11. (PMID: 27881302) J Immunol. 2016 Oct 15;197(8):3371-3381. (PMID: 27574297) J Cell Biol. 2012 Oct 29;199(3):481-96. (PMID: 23091066) J Biol Chem. 2012 Nov 16;287(47):39753-65. (PMID: 23035126) Am J Hum Genet. 2010 Feb 12;86(2):248-53. (PMID: 20159112) J Clin Invest. 2004 May;113(10):1456-64. (PMID: 15146243) J Cell Sci. 2014 Sep 1;127(Pt 17):3641-8. (PMID: 25128561) Biochim Biophys Acta. 2017 Jan;1864(1):217-230. (PMID: 27818272) Nat Immunol. 2006 Dec;7(12 ):1293-8. (PMID: 17072319) Blood. 2007 Apr 15;109(8):3244-52. (PMID: 17158226) Blood. 2010 Oct 28;116(17 ):3347-55. (PMID: 20644114) J Biol Chem. 2015 Mar 20;290(12 ):7416-25. (PMID: 25605720) J Biol Chem. 2009 Nov 6;284(45):31018-27. (PMID: 19726682) Mol Cell Biol. 2015 Oct;35(19):3381-95. (PMID: 26217011) Allergy. 2011 Sep;66(9):1193-200. (PMID: 21557750) Proc Natl Acad Sci U S A. 2001 May 8;98 (10 ):5815-20. (PMID: 11309494) Mol Cell Biol. 2009 Nov;29(21):5679-95. (PMID: 19704010) J Biol Chem. 2011 Jan 21;286(3):1999-2007. (PMID: 21087933) J Cell Biol. 2004 Mar 1;164(5):769-79. (PMID: 14993236) Toxins (Basel). 2013 Jun;5(6):1140-66. (PMID: 23888516) EMBO J. 2005 Feb 23;24(4):742-52. (PMID: 15692570) Cell Death Dis. 2014 Nov 27;5:e1547. (PMID: 25429624) Circ Res. 2008 May 23;102(10 ):1192-201. (PMID: 18420943) J Thromb Haemost. 2007 Jul;5(7):1530-7. (PMID: 17445093) J Neurosci. 2014 Sep 3;34(36):11929-47. (PMID: 25186741) Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9182-7. (PMID: 15958533) FASEB J. 2009 Nov;23 (11):3674-81. (PMID: 19587294) Traffic. 2007 Feb;8(2):89-96. (PMID: 17181773) J Immunol. 2008 Nov 15;181(10 ):7002-13. (PMID: 18981120) J Biol Chem. 2003 Oct 3;278(40):38829-39. (PMID: 12832423) Mol Cancer Res. 2007 Jun;5(6):553-67. (PMID: 17579117) Cell Mol Life Sci. 2012 Sep;69(17 ):2919-32. (PMID: 22446748) Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14337-42. (PMID: 26489655) Platelets. 2016 Dec 29;:1-14. (PMID: 28032533) J Biol Chem. 2016 Feb 12;291(7):3145-57. (PMID: 26668317) Nat Rev Cancer. 2014 Jan;14(1):49-60. (PMID: 24505619) Cell. 2009 Oct 16;139(2):299-311. (PMID: 19837033) Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3922-7. (PMID: 10097139) Calcif Tissue Int. 2014 Sep;95(3):209-17. (PMID: 24935633) Biochem J. 2009 Jan 1;417(1):391-400. (PMID: 18795891) Immunol Res. 2014 May;58(2-3):179-85. (PMID: 24522698) Sci Rep. 2015 Jul 17;5:12201. (PMID: 26183063) Mol Cell Biol. 2014 Aug;34(15):2822-32. (PMID: 24842903) Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L325-43. (PMID: 25480335) Sci Rep. 2016 Apr 12;6:24242. (PMID: 27066838) Int J Stroke. 2016 Aug;11(6):618-25. (PMID: 27312676) Science. 1996 Aug 30;273(5279):1227-31. (PMID: 8703057) Dev Cell. 2012 May 15;22(5):952-66. (PMID: 22595670) Am J Hum Genet. 2010 Feb 12;86(2):240-7. (PMID: 20159111) Platelets. 2017 Jun;28(4):333-341. (PMID: 27256961) Prog Neurobiol. 2015 Dec;135:1-20. (PMID: 26522965) Cell Mol Life Sci. 2016 May;73(9):1895-915. (PMID: 26686862) |
| معلومات مُعتمدة: | United Kingdom Biotechnology and Biological Sciences Research Council; PG/13/92/30587 United Kingdom British Heart Foundation |
| فهرسة مساهمة: | Keywords: ADAM10; TspanC8; metalloprotease; tetraspanin |
| المشرفين على المادة: | 0 (Tetraspanins) EC 3.4.24.81 (ADAM10 Protein) |
| تواريخ الأحداث: | Date Created: 20170617 Date Completed: 20170807 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5473022 |
| DOI: | 10.1042/BST20160290 |
| PMID: | 28620033 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1470-8752 |
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| DOI: | 10.1042/BST20160290 |