دورية أكاديمية
Combined venom profiling and cytotoxicity screening of the Radde's mountain viper (Montivipera raddei) and Mount Bulgar Viper (Montivipera bulgardaghica) with potent cytotoxicity against human A549 lung carcinoma cells.
| العنوان: | Combined venom profiling and cytotoxicity screening of the Radde's mountain viper (Montivipera raddei) and Mount Bulgar Viper (Montivipera bulgardaghica) with potent cytotoxicity against human A549 lung carcinoma cells. |
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| المؤلفون: | Nalbantsoy A; Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, 35100, Izmir, Turkey., Hempel BF; Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623, Berlin, Germany., Petras D; Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623, Berlin, Germany; University of California - San Diego, Skaggs School of Pharmacy & Pharmaceutical Sciences, PSB 4231, 9500, Gilman Drive, La Jolla, CA, USA., Heiss P; Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623, Berlin, Germany., Göçmen B; Zoology Section, Department of Biology, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey., Iğci N; Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Nevşehir Hacı Bektaş Veli University, Nevşehir, Turkey., Yildiz MZ; Zoology Section, Department of Biology, Faculty of Arts and Science, Adıyaman University, Adıyaman, Turkey., Süssmuth RD; Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623, Berlin, Germany. Electronic address: roderich.suessmuth@tu-berlin.de. |
| المصدر: | Toxicon : official journal of the International Society on Toxinology [Toxicon] 2017 Sep 01; Vol. 135, pp. 71-83. Date of Electronic Publication: 2017 Jun 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1962- |
| مواضيع طبية MeSH: | Proteome* , Viperidae*, Cytotoxins/*toxicity , Viper Venoms/*chemistry , Viper Venoms/*toxicity, A549 Cells ; Animals ; Cell Line ; Chlorocebus aethiops ; Female ; Humans ; Male ; Viper Venoms/enzymology |
| مستخلص: | Here we report the first characterization of the endemic Mount Bulgar Viper (Montivipera bulgardaghica) and Radde's mountain viper (Montivipera raddei) venom by a combined approach using intact mass profiling and bottom-up proteomics. The cytotoxicity screening of crude venom as well as isolated serine proteases revealed a high activity against A549 human lung carcinoma cells. By means of intact mass profiling of native and reduced venom we observed basic and acidic phospholipases type A (Copyright © 2017 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cytotoxicity; Intact mass profiling; Montivipera; Mount Bulgar Viper; Radde's mountain viper; Snake venomics |
| المشرفين على المادة: | 0 (Cytotoxins) 0 (Proteome) 0 (Viper Venoms) |
| تواريخ الأحداث: | Date Created: 20170620 Date Completed: 20181108 Latest Revision: 20220408 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.toxicon.2017.06.008 |
| PMID: | 28625888 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3150 |
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| DOI: | 10.1016/j.toxicon.2017.06.008 |