دورية أكاديمية
Combined venom profiling and cytotoxicity screening of the Radde's mountain viper (Montivipera raddei) and Mount Bulgar Viper (Montivipera bulgardaghica) with potent cytotoxicity against human A549 lung carcinoma cells.
العنوان: | Combined venom profiling and cytotoxicity screening of the Radde's mountain viper (Montivipera raddei) and Mount Bulgar Viper (Montivipera bulgardaghica) with potent cytotoxicity against human A549 lung carcinoma cells. |
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المؤلفون: | Nalbantsoy A; Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, 35100, Izmir, Turkey., Hempel BF; Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623, Berlin, Germany., Petras D; Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623, Berlin, Germany; University of California - San Diego, Skaggs School of Pharmacy & Pharmaceutical Sciences, PSB 4231, 9500, Gilman Drive, La Jolla, CA, USA., Heiss P; Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623, Berlin, Germany., Göçmen B; Zoology Section, Department of Biology, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey., Iğci N; Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Nevşehir Hacı Bektaş Veli University, Nevşehir, Turkey., Yildiz MZ; Zoology Section, Department of Biology, Faculty of Arts and Science, Adıyaman University, Adıyaman, Turkey., Süssmuth RD; Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623, Berlin, Germany. Electronic address: roderich.suessmuth@tu-berlin.de. |
المصدر: | Toxicon : official journal of the International Society on Toxinology [Toxicon] 2017 Sep 01; Vol. 135, pp. 71-83. Date of Electronic Publication: 2017 Jun 16. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1962- |
مواضيع طبية MeSH: | Proteome* , Viperidae*, Cytotoxins/*toxicity , Viper Venoms/*chemistry , Viper Venoms/*toxicity, A549 Cells ; Animals ; Cell Line ; Chlorocebus aethiops ; Female ; Humans ; Male ; Viper Venoms/enzymology |
مستخلص: | Here we report the first characterization of the endemic Mount Bulgar Viper (Montivipera bulgardaghica) and Radde's mountain viper (Montivipera raddei) venom by a combined approach using intact mass profiling and bottom-up proteomics. The cytotoxicity screening of crude venom as well as isolated serine proteases revealed a high activity against A549 human lung carcinoma cells. By means of intact mass profiling of native and reduced venom we observed basic and acidic phospholipases type A (Copyright © 2017 Elsevier Ltd. All rights reserved.) |
فهرسة مساهمة: | Keywords: Cytotoxicity; Intact mass profiling; Montivipera; Mount Bulgar Viper; Radde's mountain viper; Snake venomics |
المشرفين على المادة: | 0 (Cytotoxins) 0 (Proteome) 0 (Viper Venoms) |
تواريخ الأحداث: | Date Created: 20170620 Date Completed: 20181108 Latest Revision: 20220408 |
رمز التحديث: | 20231215 |
DOI: | 10.1016/j.toxicon.2017.06.008 |
PMID: | 28625888 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1879-3150 |
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DOI: | 10.1016/j.toxicon.2017.06.008 |