دورية أكاديمية
أعرض في EDS

Semen amyloids participate in spermatozoa selection and clearance.

التفاصيل البيبلوغرافية
العنوان: Semen amyloids participate in spermatozoa selection and clearance.
المؤلفون: Roan NR; Department or Urology, University of California San Francisco, San Francisco, United States.; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States., Sandi-Monroy N; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.; Kinderwunsch-Zentrum, Ulm, Germany., Kohgadai N; Department or Urology, University of California San Francisco, San Francisco, United States.; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States., Usmani SM; The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, United States., Hamil KG; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, United States., Neidleman J; Department or Urology, University of California San Francisco, San Francisco, United States.; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States., Montano M; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States., Ständker L; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.; Core Facility Functional Peptidomics, Ulm University, Ulm, Germany., Röcker A; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Cavrois M; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States.; Department of Medicine, University of California San Francisco, San Francisco, United States., Rosen J; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, United States., Marson K; HIV / AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, United States., Smith JF; Department or Urology, University of California San Francisco, San Francisco, United States., Pilcher CD; HIV / AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, United States., Gagsteiger F; Kinderwunsch-Zentrum, Ulm, Germany., Sakk O; Core Facility Transgenic Mice, Medical Faculty, Ulm University, Ulm, Germany., O'Rand M; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, United States., Lishko PV; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, United States., Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Münch J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Greene WC; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States.; Department of Medicine, University of California San Francisco, San Francisco, United States.; Department of Microbiology and Immunology, University of California, San Francisco, United States.
المصدر: ELife [Elife] 2017 Jun 27; Vol. 6. Date of Electronic Publication: 2017 Jun 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Cell Adhesion*, Amyloid/*metabolism , Semen/*chemistry , Semen/*cytology , Spermatozoa/*physiology, Humans ; Macrophages/physiology ; Male ; Phagocytosis
مستخلص: Unlike other human biological fluids, semen contains multiple types of amyloid fibrils in the absence of disease. These fibrils enhance HIV infection by promoting viral fusion to cellular targets, but their natural function remained unknown. The similarities shared between HIV fusion to host cell and sperm fusion to oocyte led us to examine whether these fibrils promote fertilization. Surprisingly, the fibrils inhibited fertilization by immobilizing sperm. Interestingly, however, this immobilization facilitated uptake and clearance of sperm by macrophages, which are known to infiltrate the female reproductive tract (FRT) following semen exposure. In the presence of semen fibrils, damaged and apoptotic sperm were more rapidly phagocytosed than healthy ones, suggesting that deposition of semen fibrils in the lower FRT facilitates clearance of poor-quality sperm. Our findings suggest that amyloid fibrils in semen may play a role in reproduction by participating in sperm selection and facilitating the rapid removal of sperm antigens.
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معلومات مُعتمدة: P01 AI083050 United States AI NIAID NIH HHS; R21 AI116252 United States AI NIAID NIH HHS; P30 AI027763 United States AI NIAID NIH HHS; R01 AI127219 United States AI NIAID NIH HHS; R00 AI104262 United States AI NIAID NIH HHS; P50 HD055764 United States HD NICHD NIH HHS; K99 AI104262 United States AI NIAID NIH HHS; R01 HD074511 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: Amyloid; Reproduction; Semen; biophysics; human; human biology; medicine; structural biology
المشرفين على المادة: 0 (Amyloid)
تواريخ الأحداث: Date Created: 20170628 Date Completed: 20180312 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5487211
DOI: 10.7554/eLife.24888
PMID: 28653619
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.24888