دورية أكاديمية
Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models.
العنوان: | Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models. |
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المؤلفون: | Maulik M; Department of Chemistry and Biochemistry, University of Alaska FairbanksFairbanks, AK, United States., Mitra S; Department of Chemistry and Biochemistry, University of Alaska FairbanksFairbanks, AK, United States., Bult-Ito A; Department of Biology and Wildlife, University of Alaska FairbanksFairbanks, AK, United States., Taylor BE; Department of Biological Sciences, California State University, Long BeachLong Beach, CA, United States., Vayndorf EM; Institute of Arctic Biology, University of Alaska FairbanksFairbanks, AK, United States. |
المصدر: | Frontiers in genetics [Front Genet] 2017 Jun 13; Vol. 8, pp. 77. Date of Electronic Publication: 2017 Jun 13 (Print Publication: 2017). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation. |
مستخلص: | Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in cells of the substantia nigra in the brain and loss of dopaminergic neurons. This pathology is associated with impaired movement and reduced cognitive function. The etiology of PD can be attributed to a combination of environmental and genetic factors. A popular animal model, the nematode roundworm Caenorhabditis elegans , has been frequently used to study the role of genetic and environmental factors in the molecular pathology and behavioral phenotypes associated with PD. The current review summarizes cellular markers and behavioral phenotypes in transgenic and toxin-induced PD models of C. elegans . |
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معلومات مُعتمدة: | P20 GM103395 United States GM NIGMS NIH HHS; RL5 GM118990 United States GM NIGMS NIH HHS; TL4 GM118992 United States GM NIGMS NIH HHS; UL1 GM118991 United States GM NIGMS NIH HHS |
فهرسة مساهمة: | Keywords: Caenorhabditis elegans (C. elegans); Parkinson's disease (PD); behavioral phenotyping; dopamine; pathological markers |
تواريخ الأحداث: | Date Created: 20170630 Latest Revision: 20200930 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5468440 |
DOI: | 10.3389/fgene.2017.00077 |
PMID: | 28659967 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-8021 |
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DOI: | 10.3389/fgene.2017.00077 |