دورية أكاديمية
أعرض في EDS

Effects of Selective Deletion of Tyrosine Hydroxylase from Kisspeptin Cells on Puberty and Reproduction in Male and Female Mice.

التفاصيل البيبلوغرافية
العنوان: Effects of Selective Deletion of Tyrosine Hydroxylase from Kisspeptin Cells on Puberty and Reproduction in Male and Female Mice.
المؤلفون: Stephens SBZ; Department of Reproductive Medicine, University of California, San Diego La Jolla, CA 92093., Rouse ML; Department of Reproductive Medicine, University of California, San Diego La Jolla, CA 92093., Tolson KP; Department of Reproductive Medicine, University of California, San Diego La Jolla, CA 92093., Liaw RB; Department of Reproductive Medicine, University of California, San Diego La Jolla, CA 92093., Parra RA; Department of Reproductive Medicine, University of California, San Diego La Jolla, CA 92093., Chahal N; Department of Reproductive Medicine, University of California, San Diego La Jolla, CA 92093., Kauffman AS; Department of Reproductive Medicine, University of California, San Diego La Jolla, CA 92093.
المصدر: ENeuro [eNeuro] 2017 Jun 22; Vol. 4 (3). Date of Electronic Publication: 2017 Jun 22 (Print Publication: 2017).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: eCollection Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Washington, DC] : Society for Neuroscience, [2014]-
مواضيع طبية MeSH: Kisspeptins/*metabolism , Neurons/*enzymology , Reproduction/*physiology , Sexual Maturation/*physiology , Tyrosine 3-Monooxygenase/*deficiency, Animals ; Arcuate Nucleus of Hypothalamus/metabolism ; Body Weight/physiology ; Dopamine/metabolism ; Estradiol/administration & dosage ; Estradiol/metabolism ; Female ; Fertility/physiology ; Gonadotropins/metabolism ; Kisspeptins/genetics ; Longitudinal Studies ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Paraventricular Hypothalamic Nucleus/metabolism ; Testosterone/metabolism ; Tyrosine 3-Monooxygenase/genetics
مستخلص: The neuropeptide kisspeptin, encoded by Kiss1 , regulates reproduction by stimulating GnRH secretion. Kiss1- syntheizing neurons reside primarily in the hypothalamic anteroventral periventricular (AVPV/PeN) and arcuate (ARC) nuclei. AVPV/PeN Kiss1 neurons are sexually dimorphic, with females expressing more Kiss1 than males, and participate in estradiol (E 2 )-induced positive feedback control of GnRH secretion. In mice, most AVPV/PeN Kiss1 cells coexpress tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis (in this case, dopamine). Dopamine treatment can inhibit GnRH neurons, but the function of dopamine signaling arising specifically from AVPV/PeN Kiss1 cells is unknown. We generated a novel TH flox mouse and used Cre-Lox technology to selectively ablate TH specifically from Kiss1 cells. We then examined the effects of selective TH knock-out on puberty and reproduction in both sexes. In control mice, 90% of AVPV/PeN Kiss1 neurons coexpressed TH , whereas in mice lacking TH exclusively in Kiss1 cells (termed Kiss THKOs), TH was successfully absent from virtually all Kiss1 cells. Despite this absence of TH , both female and male Kiss THKOs displayed normal body weights, puberty onset, and basal gonadotropin levels in adulthood, although testosterone (T) was significantly elevated in adult male Kiss THKOs. The E 2 -induced LH surge was unaffected in Kiss THKO females, and neuronal activation status of kisspeptin and GnRH cells was also normal. Supporting this, fertility and fecundity were normal in Kiss THKOs of both sexes. Thus, despite high colocalization of TH and Kiss1 in the AVPV/PeN, dopamine produced in these cells is not required for puberty or reproduction, and its function remains unknown.
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معلومات مُعتمدة: R01 HD082567 United States HD NICHD NIH HHS; K12 GM068524 United States GM NIGMS NIH HHS; T32 HD007203 United States HD NICHD NIH HHS; P50 HD028934 United States HD NICHD NIH HHS; F32 HD088060 United States HD NICHD NIH HHS; P50 HD012303 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: GnRH; Kiss1; dopamine; kisspeptin; puberty; reproduction
المشرفين على المادة: 0 (Gonadotropins)
0 (Kiss1 protein, mouse)
0 (Kisspeptins)
3XMK78S47O (Testosterone)
4TI98Z838E (Estradiol)
EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
VTD58H1Z2X (Dopamine)
تواريخ الأحداث: Date Created: 20170630 Date Completed: 20180402 Latest Revision: 20230804
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5480141
DOI: 10.1523/ENEURO.0150-17.2017
PMID: 28660243
قاعدة البيانات: MEDLINE
الوصف
تدمد:2373-2822
DOI:10.1523/ENEURO.0150-17.2017