دورية أكاديمية

α-Glucosidase Inhibitory Xanthones from the Roots of Garcinia fusca.

التفاصيل البيبلوغرافية
العنوان: α-Glucosidase Inhibitory Xanthones from the Roots of Garcinia fusca.
المؤلفون: Nguyen NK; Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam., Truong XA; Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam., Bui TQ; Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam., Bui DN; Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam., Nguyen HX; Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam., Tran PT; Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam., Nguyen LD; Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam.
المصدر: Chemistry & biodiversity [Chem Biodivers] 2017 Oct; Vol. 14 (10). Date of Electronic Publication: 2017 Sep 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-
مواضيع طبية MeSH: Garcinia/*chemistry , Glycoside Hydrolase Inhibitors/*pharmacology , Plant Roots/*chemistry , Xanthones/*pharmacology, Dose-Response Relationship, Drug ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/isolation & purification ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Xanthones/chemistry ; Xanthones/isolation & purification ; alpha-Glucosidases/metabolism
مستخلص: Two new compounds, fuscaxanthones J (1) and K (2), together with eight known xanthones (3 - 10) were isolated from an ethyl acetate extract of the roots of Garcinia fusca. Their structures were determined using spectroscopic methods, mainly 1D- and 2D-NMR. α-Glucosidase inhibitory activity of the isolated compounds was evaluated and fuscaxanthone J (1) showed the most significant effect with an IC 50 value of 8.3 ± 1.8 μm (compared with acarbose, IC 50 = 214.5 ± 2.3 μm).
(© 2017 Wiley-VHCA AG, Zurich, Switzerland.)
فهرسة مساهمة: Keywords: Garcinia fusca; Fuscaxanthones J and K; Xanthones; α-Glucosidase inhibitory activity
المشرفين على المادة: 0 (Glycoside Hydrolase Inhibitors)
0 (Xanthones)
EC 3.2.1.20 (alpha-Glucosidases)
تواريخ الأحداث: Date Created: 20170701 Date Completed: 20171128 Latest Revision: 20171128
رمز التحديث: 20221213
DOI: 10.1002/cbdv.201700232
PMID: 28665538
قاعدة البيانات: MEDLINE
الوصف
تدمد:1612-1880
DOI:10.1002/cbdv.201700232