دورية أكاديمية
أعرض في EDS

Amount of fear extinction changes its underlying mechanisms.

التفاصيل البيبلوغرافية
العنوان: Amount of fear extinction changes its underlying mechanisms.
المؤلفون: An B; School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.; Department of Neurobiology, Duke University, Durham, United States., Kim J; School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea., Park K; School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea., Lee S; School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.; Department of Neural Development and Disease, Korea Brain Research Institute, Daegu, Korea., Song S; School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea., Choi S; School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.
المصدر: ELife [Elife] 2017 Jul 03; Vol. 6. Date of Electronic Publication: 2017 Jul 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Extinction, Psychological* , Fear*, Amygdala/*physiology , Prefrontal Cortex/*physiology, Animals ; Conditioning, Classical ; Rats
مستخلص: There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-session extinction training and its repetition (multiple-session extinction training), we investigated the inhibition and erasure mechanisms in the prefrontal cortex and amygdala of rats, where neural circuits underlying extinction reside. The inhibition mechanism was prevalent with single-session extinction training but faded when single-session extinction training was repeated. In contrast, the erasure mechanism became prevalent when single-session extinction training was repeated. Moreover, ablating the intercalated neurons of amygdala, which are responsible for maintaining extinction-induced inhibition, was no longer effective in multiple-session extinction training. We propose that the inhibition mechanism operates primarily in the early phase of extinction training, and the erasure mechanism takes over after that.
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فهرسة مساهمة: Keywords: amygdala intercalated neurons; basal nucleus of amygdala; fear extinction; lateral amygdala; neuroscience; prefrontal cortex; rat
تواريخ الأحداث: Date Created: 20170704 Date Completed: 20180309 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5495569
DOI: 10.7554/eLife.25224
PMID: 28671550
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.25224