دورية أكاديمية
أعرض في EDS

Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.

التفاصيل البيبلوغرافية
العنوان: Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.
المؤلفون: Khan KA; Molecular Angiogenesis Laboratory, Institutes of Biomedical Research and Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Naylor AJ; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Khan A; Molecular Angiogenesis Laboratory, Institutes of Biomedical Research and Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Noy PJ; Molecular Angiogenesis Laboratory, Institutes of Biomedical Research and Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Mambretti M; Molecular Angiogenesis Laboratory, Institutes of Biomedical Research and Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Lodhia P; Molecular Angiogenesis Laboratory, Institutes of Biomedical Research and Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Athwal J; Molecular Angiogenesis Laboratory, Institutes of Biomedical Research and Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Korzystka A; Molecular Angiogenesis Laboratory, Institutes of Biomedical Research and Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Buckley CD; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Willcox BE; Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Mohammed F; Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Bicknell R; Molecular Angiogenesis Laboratory, Institutes of Biomedical Research and Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
المصدر: Oncogene [Oncogene] 2017 Nov 02; Vol. 36 (44), pp. 6097-6108. Date of Electronic Publication: 2017 Jul 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
أسماء مطبوعة: Publication: <2002->: Basingstoke : Nature Publishing Group
Original Publication: Basingstoke, Hampshire, UK : Scientific & Medical Division, MacMillan Press, c1987-
مواضيع طبية MeSH: Antigens, CD/*genetics , Antigens, Neoplasm/*genetics , Antigens, Surface/*genetics , Cell Adhesion Molecules/*genetics , Lectins, C-Type/*genetics , Membrane Glycoproteins/*genetics , Neovascularization, Pathologic/*genetics , Pancreatic Neoplasms/*genetics , Receptors, Complement/*genetics, Animals ; Antigens, CD/metabolism ; Antigens, Neoplasm/metabolism ; Antigens, Surface/metabolism ; Cell Adhesion Molecules/metabolism ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Human Umbilical Vein Endothelial Cells ; Humans ; Lectins, C-Type/metabolism ; Ligands ; Membrane Glycoproteins/metabolism ; Mice ; Neovascularization, Pathologic/pathology ; Pancreatic Neoplasms/pathology ; Pericytes/metabolism ; Pericytes/pathology ; Protein Binding ; Receptors, Complement/metabolism ; Thrombomodulin/genetics ; Thrombomodulin/metabolism
مستخلص: The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pericytes. Multimerin-2 (MMRN2) is a unique endothelial specific extracellular matrix protein that has been implicated in angiogenesis and tumour progression. We show that the group 14 C-type lectins CLEC14A, CD93 and CD248 directly bind to MMRN2 and only thrombomodulin of the family does not. Binding to MMRN2 is dependent on a predicted long-loop region in the C-type lectin domain and is abrogated by mutation within the domain. CLEC14A and CD93 bind to the same non-glycosylated coiled-coil region of MMRN2, but the binding of CD248 occurs on a distinct non-competing region. CLEC14A and CD248 can bind MMRN2 simultaneously and this occurs at the interface between endothelium and pericytes in human pancreatic cancer. A recombinant peptide of MMRN2 spanning the CLEC14A and CD93 binding region blocks CLEC14A extracellular domain binding to the endothelial cell surface as well as increasing adherence of human umbilical vein endothelial cells to the active peptide. This MMRN2 peptide is anti-angiogenic in vitro and reduces tumour growth in mouse models. These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation.
References: Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):657-64. (PMID: 21148427)
World J Gastroenterol. 2005 Mar 7;11(9):1283-6. (PMID: 15761964)
Oncogene. 2013 Nov 28;32(48):5449-57. (PMID: 23644659)
Oncogene. 2012 Jan 19;31(3):293-305. (PMID: 21706054)
Anal Biochem. 1999 Jan 1;266(1):9-15. (PMID: 9887208)
Oncogene. 2015 Nov 19;34(47):5821-31. (PMID: 25745997)
Blood. 2012 Aug 16;120(7):1516-27. (PMID: 22740442)
J Cutan Pathol. 2006 Feb;33(2):145-55. (PMID: 16420310)
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17965-70. (PMID: 17986615)
FEBS J. 2005 Dec;272(24):6179-217. (PMID: 16336259)
Cancer Res. 2015 Nov 1;75(21):4504-16. (PMID: 26363010)
Mod Pathol. 2008 Mar;21(3):308-15. (PMID: 18192970)
J Biol Chem. 2001 Dec 21;276(51):48588-95. (PMID: 11559704)
FASEB J. 2016 Jun;30(6):2311-23. (PMID: 26939791)
Angiogenesis. 2001;4(2):113-21. (PMID: 11806243)
Biochem Biophys Res Commun. 2016 Aug 5;476(4):467-474. (PMID: 27255994)
Neoplasma. 2016;63(2):183-92. (PMID: 26774137)
J Immunol. 2005 Jul 15;175(2):1239-47. (PMID: 16002728)
Clin Cancer Res. 2015 Mar 15;21(6):1281-8. (PMID: 25398449)
Oncotarget. 2016 Jan 12;7(2):2022-37. (PMID: 26655500)
J Cell Sci. 2014 Jul 15;127(Pt 14):3039-51. (PMID: 24928894)
J Neuropathol Exp Neurol. 2004 Dec;63(12):1274-83. (PMID: 15624764)
Biochem Biophys Res Commun. 2011 Jan 7;404(1):103-8. (PMID: 21095181)
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W289-94. (PMID: 15980472)
Oncogene. 2012 Jun 28;31(26):3136-47. (PMID: 22020326)
Nat Methods. 2015 Jan;12(1):7-8. (PMID: 25549265)
J Immunol. 2002 May 15;168(10):5222-32. (PMID: 11994479)
J Biol Chem. 2001 Oct 19;276(42):38795-807. (PMID: 11489895)
Mol Cell Proteomics. 2013 Dec;12(12):3599-611. (PMID: 23979707)
Immunity. 1999 Jun;10(6):691-700. (PMID: 10403644)
Int J Colorectal Dis. 2015 Jul;30(7):883-90. (PMID: 26008729)
J Immunol. 1998 Feb 15;160(4):1929-35. (PMID: 9469455)
Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1243-50. (PMID: 17001101)
Cancer Cell. 2013 Aug 12;24(2):229-41. (PMID: 23871637)
Nat Med. 2003 Jun;9(6):653-60. (PMID: 12778163)
Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):757-66. (PMID: 9757090)
J Biol Chem. 1991 Oct 25;266(30):20345-55. (PMID: 1939090)
Arthritis Rheum. 2012 Oct;64(10 ):3334-43. (PMID: 22674221)
معلومات مُعتمدة: 19791 United Kingdom ARC_ Arthritis Research UK; 19791 United Kingdom VAC_ Versus Arthritis
المشرفين على المادة: 0 (Antigens, CD)
0 (Antigens, Neoplasm)
0 (Antigens, Surface)
0 (CD248 protein, human)
0 (CLEC14A protein, human)
0 (Cell Adhesion Molecules)
0 (EMILIN3 protein, human)
0 (Lectins, C-Type)
0 (Ligands)
0 (Membrane Glycoproteins)
0 (Receptors, Complement)
0 (Thrombomodulin)
0 (complement 1q receptor)
تواريخ الأحداث: Date Created: 20170704 Date Completed: 20171120 Latest Revision: 20210109
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5671938
DOI: 10.1038/onc.2017.214
PMID: 28671670
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5594
DOI:10.1038/onc.2017.214