دورية أكاديمية
Multielectron Chemistry within a Model Nickel Metalloprotein: Mechanistic Implications for Acetyl-CoA Synthase.
العنوان: | Multielectron Chemistry within a Model Nickel Metalloprotein: Mechanistic Implications for Acetyl-CoA Synthase. |
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المؤلفون: | Manesis AC; The Ohio State University , 100 West 18th Avenue, Newman & Wolfrom Laboratory of Chemistry, Columbus, Ohio 43210, United States., O'Connor MJ; The Ohio State University , 100 West 18th Avenue, Newman & Wolfrom Laboratory of Chemistry, Columbus, Ohio 43210, United States., Schneider CR; The Ohio State University , 100 West 18th Avenue, Newman & Wolfrom Laboratory of Chemistry, Columbus, Ohio 43210, United States., Shafaat HS; The Ohio State University , 100 West 18th Avenue, Newman & Wolfrom Laboratory of Chemistry, Columbus, Ohio 43210, United States. |
المصدر: | Journal of the American Chemical Society [J Am Chem Soc] 2017 Aug 02; Vol. 139 (30), pp. 10328-10338. Date of Electronic Publication: 2017 Jul 21. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington, DC : American Chemical Society Original Publication: Easton, Pa. [etc.] |
مواضيع طبية MeSH: | Acetate-CoA Ligase/*metabolism , Carbon Monoxide/*chemistry , Metalloproteins/*chemistry , Nickel/*chemistry, Acetate-CoA Ligase/chemistry ; Carbon Monoxide/metabolism ; Electrons ; Metalloproteins/isolation & purification ; Metalloproteins/metabolism ; Models, Molecular ; Nickel/metabolism ; Oxidation-Reduction ; Pseudomonas aeruginosa/enzymology |
مستخلص: | The acetyl coenzyme A synthase (ACS) enzyme plays a central role in the metabolism of anaerobic bacteria and archaea, catalyzing the reversible synthesis of acetyl-CoA from CO and a methyl group through a series of nickel-based organometallic intermediates. Owing to the extreme complexity of the native enzyme systems, the mechanism by which this catalysis occurs remains poorly understood. In this work, we have developed a protein-based model for the Ni |
المشرفين على المادة: | 0 (Metalloproteins) 7OV03QG267 (Nickel) 7U1EE4V452 (Carbon Monoxide) EC 6.2.1.1 (Acetate-CoA Ligase) |
تواريخ الأحداث: | Date Created: 20170706 Date Completed: 20180531 Latest Revision: 20180531 |
رمز التحديث: | 20240628 |
DOI: | 10.1021/jacs.7b03892 |
PMID: | 28675928 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-5126 |
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DOI: | 10.1021/jacs.7b03892 |