دورية أكاديمية
أعرض في EDS

Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury.

التفاصيل البيبلوغرافية
العنوان: Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury.
المؤلفون: Gugliandolo E; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, no 31, Messina 98166, Italy. Electronic address: egugliandolo@unime.it., Fusco R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, no 31, Messina 98166, Italy. Electronic address: rfusco@unime.it., Biundo F; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, no 31, Messina 98166, Italy. Electronic address: fbiundo@unime.it., D'Amico R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, no 31, Messina 98166, Italy. Electronic address: ramonadamico90@gmail.com., Benedetto F; Department of Vascular and Thoracic Surgery, University of Messina, Messina, Italy. Electronic address: filippo.benedetto@unime.it., Di Paola R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, no 31, Messina 98166, Italy. Electronic address: dipaolar@unime.it., Cuzzocrea S; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, no 31, Messina 98166, Italy; Department of Pharmacological and Physiological Science, Saint Louis University, USA. Electronic address: salvator@unime.it.
المصدر: Pharmacological research [Pharmacol Res] 2017 Sep; Vol. 123, pp. 83-92. Date of Electronic Publication: 2017 Jul 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Oct. 2015- : Amsterdam ; Elsevier
Original Publication: London ; San Diego : Academic Press, c1989-
مواضيع طبية MeSH: Anti-Inflammatory Agents/*therapeutic use , Carotid Artery Injuries/*drug therapy , Ethanolamines/*therapeutic use , Glucosides/*therapeutic use , Palmitic Acids/*therapeutic use , Stilbenes/*therapeutic use , Vascular System Injuries/*drug therapy, Amides ; Animals ; Anti-Inflammatory Agents/pharmacology ; Aorta/drug effects ; Aorta/physiology ; Apoptosis/drug effects ; Carotid Arteries/drug effects ; Carotid Arteries/metabolism ; Carotid Arteries/pathology ; Carotid Artery Injuries/metabolism ; Carotid Artery Injuries/pathology ; Cytokines/metabolism ; Drug Therapy, Combination ; Ethanolamines/pharmacology ; Glucosides/pharmacology ; Intercellular Adhesion Molecule-1/metabolism ; Mice, Inbred C57BL ; NF-KappaB Inhibitor alpha/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Norepinephrine/pharmacology ; Oxidative Stress/drug effects ; Palmitic Acids/pharmacology ; Stilbenes/pharmacology ; Transcription Factor RelA/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism ; Vascular System Injuries/metabolism ; Vascular System Injuries/pathology
مستخلص: Acute and chronic inflammation responses are important risk factors for vascular remodeling processes such as in atherosclerosis, arteriosclerosis and restenosis. Inflammation and oxidative stress in the intimal region after vascular damage are a key event in the development of neointimal hyperplasia. In this study, we used this model of vascular damage, which involves the complete ligature of the left carotid artery for 14days, to observe the role of N-palmitoylethanolamine in combination with Polydatin at the dose of 30mg/kg, on regulation of inflammatory process, and oxidative stress. Palmitoylethanolamide (PEA), an endogenous fatty acid amide belonging to the N-acylethanolamine family, has anti-inflammatory and neuroprotective effects. However, PEA lacks direct capacity to prevent formation of free radicals. Polydatin (PLD) that is a natural precursor of resveratrol has antioxidant activity. Thus, the combination of PEA and PLD could have beneficial effects on inflammatory process and oxidative stress. This model shows that 14days after carotid artery ligation there is a significant structural change within the vessel, and that there is an important involvement of the inflammatory pathway in the progression of this disease. In this study we demonstrated that PEA/PLD combination treatment reduces vessel damage, adhesion molecules expression such as intercellular adhesion molecules-1(ICAM-1) and vascular cell adhesion molecules-1(V-CAM), proinflammatory cytokines production (Tumor Necrosis Factor alpha (TNF-α) and Interleukin 1 beta (IL-1β), the inducible nitric oxide synthase (iNOS) and Poly (ADP-ribose) polymerase (PAR), formation, Nuclear factor kappa-B expression and apoptosis (BAX, Fas-Ligand) activation. Our results clearly demonstrated that treatment with PEA/PLD 30mg/Kg is able to reduce vascular damage and attenuates the inflammatory process.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
التعليقات: Erratum in: Pharmacol Res. 2024 Feb 16;:107110. (PMID: 38368184)
فهرسة مساهمة: Keywords: Inflammation; Oxidative stress; Palmitoylethanolamide; Palmitoylethanolamide (PubChem CID: 4671); Polydatin; Polydatin (PubChem: 5281718); Vascular disease
المشرفين على المادة: 0 (Amides)
0 (Anti-Inflammatory Agents)
0 (Cytokines)
0 (Ethanolamines)
0 (Glucosides)
0 (Palmitic Acids)
0 (Stilbenes)
0 (Transcription Factor RelA)
0 (Vascular Cell Adhesion Molecule-1)
126547-89-5 (Intercellular Adhesion Molecule-1)
139874-52-5 (NF-KappaB Inhibitor alpha)
6R8T1UDM3V (palmidrol)
EC 1.14.13.39 (Nitric Oxide Synthase Type II)
EC 1.14.13.39 (Nos2 protein, mouse)
X4W3ENH1CV (Norepinephrine)
XM261C37CQ (polydatin)
تواريخ الأحداث: Date Created: 20170706 Date Completed: 20180510 Latest Revision: 20240217
رمز التحديث: 20240218
DOI: 10.1016/j.phrs.2017.06.014
PMID: 28676456
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-1186
DOI:10.1016/j.phrs.2017.06.014