دورية أكاديمية
Patterns and predictors of first and subsequent recurrence in women with early breast cancer.
| العنوان: | Patterns and predictors of first and subsequent recurrence in women with early breast cancer. |
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| المؤلفون: | Geurts YM; Department of Research, Netherlands Comprehensive Cancer Organisation, Postbus 217, 7500 AE, Enschede, The Netherlands., Witteveen A; Department of Health Technology and Service Research, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Postbus 217, 7500 AE, Enschede, The Netherlands. a.witteveen@utwente.nl., Bretveld R; Department of Research, Netherlands Comprehensive Cancer Organisation, Postbus 217, 7500 AE, Enschede, The Netherlands., Poortmans PM; Department of Radiation Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands., Sonke GS; Department of Medical Oncology, Netherlands Cancer Institute, Postbus 90203, 1006 BE, Amsterdam, The Netherlands., Strobbe LJA; Department of Surgical Oncology, Canisius-Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands., Siesling S; Department of Health Technology and Service Research, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Postbus 217, 7500 AE, Enschede, The Netherlands.; Department of Research, Netherlands Comprehensive Cancer Organisation, Postbus 217, 7500 AE, Enschede, The Netherlands. |
| المصدر: | Breast cancer research and treatment [Breast Cancer Res Treat] 2017 Oct; Vol. 165 (3), pp. 709-720. Date of Electronic Publication: 2017 Jul 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dordrecht : Kluwer Academic Original Publication: The Hague ; Boston : M. Nijhoff, c1981- |
| مواضيع طبية MeSH: | Breast Neoplasms/*epidemiology , Breast Neoplasms/*pathology, Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/mortality ; Breast Neoplasms/therapy ; Combined Modality Therapy ; Female ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Netherlands/epidemiology ; Patient Outcome Assessment ; Prognosis ; Registries ; Tumor Burden |
| مستخلص: | Purpose: Little is known about the occurrence, timing and prognostic factors for first and also subsequent local (LR), regional (RR) or distant (DM) breast cancer recurrence. As current follow-up is still consensus-based, more information on the patterns and predictors of subsequent recurrences can inform more personalized follow-up decisions. Methods: Women diagnosed with stage I-III invasive breast cancer who were treated with curative intent were selected from the Netherlands Cancer Registry (N = 9342). Extended Cox regression was used to model the hazard of recurrence over ten years of follow-up for not only site-specific first, but also subsequent recurrences after LR or RR. Results: In total, 362 patients had LR, 148 RR and 1343 DM as first recurrence. The risk of first recurrence was highest during the second year post-diagnosis (3.9%; 95% CI 3.5-4.3) with similar patterns for LR, RR and DM. Young age (<40), tumour size >2 cm, tumour grade II/III, positive lymph nodes, multifocality and no chemotherapy were prognostic factors for first recurrence. The risk of developing a second recurrence after LR or RR (N = 176) was significantly higher after RR than after LR (50 vs 29%; p < 0.001). After a second LR or RR, more than half of the women were diagnosed with a third recurrence. Conclusions: Although the risk of subsequent recurrence is high, absolute incidence remains low. Also, almost half the second recurrences are detected in the first year after previous recurrence and more than 80% are DM. This suggests that more intensive follow-up for early detection subsequent recurrence is not likely to be (cost-)effective. |
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| فهرسة مساهمة: | Keywords: Breast cancer; Follow-up; Prognostic factors; Recurrence patterns; Recurrence risk |
| تواريخ الأحداث: | Date Created: 20170706 Date Completed: 20180703 Latest Revision: 20190123 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5602040 |
| DOI: | 10.1007/s10549-017-4340-3 |
| PMID: | 28677011 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-7217 |
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| DOI: | 10.1007/s10549-017-4340-3 |