دورية أكاديمية
Impedance feedback control of microfluidic valves for reliable post processing combinatorial droplet injection.
| العنوان: | Impedance feedback control of microfluidic valves for reliable post processing combinatorial droplet injection. |
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| المؤلفون: | Axt B; Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Clark Hall 118B, Baltimore, MD, 21218, USA., Hsieh YF; Department of Mechanical Engineering, Johns Hopkins University, 3400 N. Charles Street, Shaffer Hall 200A, Baltimore, MD, 21218, USA., Nalayanda D; Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Clark Hall 118B, Baltimore, MD, 21218, USA., Wang TH; Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Clark Hall 118B, Baltimore, MD, 21218, USA. thwang@jhu.edu.; Department of Mechanical Engineering, Johns Hopkins University, 3400 N. Charles Street, Shaffer Hall 200A, Baltimore, MD, 21218, USA. thwang@jhu.edu. |
| المصدر: | Biomedical microdevices [Biomed Microdevices] 2017 Sep; Vol. 19 (3), pp. 61. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer US Country of Publication: United States NLM ID: 100887374 Publication Model: Print Cited Medium: Internet ISSN: 1572-8781 (Electronic) Linking ISSN: 13872176 NLM ISO Abbreviation: Biomed Microdevices Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer US Original Publication: Boston : Kluwer Academic Publishers, 1998- |
| مواضيع طبية MeSH: | Feedback* , Lab-On-A-Chip Devices*, Injections/*instrumentation, Electric Impedance ; Equipment Design |
| مستخلص: | Droplet microfluidics has found use in many biological assay applications as a means of high-throughput sample processing. One of the challenges of the technology, however, is the ability to control and merge droplets on-demand as they flow through the microdevices. It is in the interest of developing lab-on-chip devices to be able to combinatorically program additive mixing steps for more complex multistep and multiplex assays. Existing technologies to merge droplets are either passive in nature or require highly predictable droplet movement for feedforward control, making them vulnerable to errors during high throughput operation. In this paper, we describe and demonstrate a microfluidic valve-based device for the purpose of combinatorial droplet injection at any stage in a multistep assay. Microfluidic valves are used to robustly control fluid flow, droplet generation, and droplet mixing in the device on-demand, while on-chip impedance measurements taken in real time are used as feedback to accurately time the droplet injections. The presented system is contrasted to attempts without feedback, and is shown to be 100% reliable over long durations. Additionally, content detection and discretionary injections are explored and successfully executed. |
| فهرسة مساهمة: | Keywords: Droplet detection; Droplet microfluidics; Feedback control; Impedance |
| تواريخ الأحداث: | Date Created: 20170707 Date Completed: 20180320 Latest Revision: 20180320 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s10544-017-0203-2 |
| PMID: | 28681238 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1572-8781 |
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| DOI: | 10.1007/s10544-017-0203-2 |