دورية أكاديمية
أعرض في EDS

The metabolic effects of diuron in the rat liver.

التفاصيل البيبلوغرافية
العنوان: The metabolic effects of diuron in the rat liver.
المؤلفون: da Silva Simões M; Department of Biochemistry, Maringá University, 87020900 Maringá, Brazil., Bracht L; Department of Biochemistry, Maringá University, 87020900 Maringá, Brazil., Parizotto AV; Department of Biochemistry, Maringá University, 87020900 Maringá, Brazil., Comar JF; Department of Biochemistry, Maringá University, 87020900 Maringá, Brazil., Peralta RM; Department of Biochemistry, Maringá University, 87020900 Maringá, Brazil., Bracht A; Department of Biochemistry, Maringá University, 87020900 Maringá, Brazil. Electronic address: adebracht@uol.com.br.
المصدر: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2017 Sep; Vol. 54, pp. 53-61. Date of Electronic Publication: 2017 Jun 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9612020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7077 (Electronic) Linking ISSN: 13826689 NLM ISO Abbreviation: Environ Toxicol Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier Science B.V., c1996-
مواضيع طبية MeSH: Diuron/*toxicity , Herbicides/*toxicity , Liver/*drug effects, Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Energy Metabolism/drug effects ; Fructose/metabolism ; Gluconeogenesis/drug effects ; Glucose/metabolism ; Lactic Acid/metabolism ; Liver/metabolism ; Male ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/metabolism ; Pyruvic Acid/metabolism ; Rats, Wistar
مستخلص: A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are dependent of ATP generated within the mitochondria. Conversely, it stimulated glycolysis and fructolysis, which are compensatory phenomena for an inhibited mitochondrial ATP generation. Furthermore, diuron diminished the cellular ATP content under conditions where the mitochondrial respiratory chain was the only source of this compound. Besides the lack of circulating glucose due to gluconeogenesis inhibition, one can expect metabolic acidosis due to excess lactate production, impairment of ammonia detoxification and cell damage due to a deficient maintenance of its homeostasis. Some of the general signs of toxicity that were observed in diuron-treated rats can be attributed, partly at least, to the effects of the herbicide on energy metabolism.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Energy metabolism; Herbicides; Liver toxicity; Phosphorylation
المشرفين على المادة: 0 (Herbicides)
30237-26-4 (Fructose)
33X04XA5AT (Lactic Acid)
8558G7RUTR (Pyruvic Acid)
8L70Q75FXE (Adenosine Triphosphate)
9I3SDS92WY (Diuron)
EC 3.6.1.- (Adenosine Triphosphatases)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20170707 Date Completed: 20171130 Latest Revision: 20171130
رمز التحديث: 20240628
DOI: 10.1016/j.etap.2017.06.024
PMID: 28683350
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7077
DOI:10.1016/j.etap.2017.06.024