دورية أكاديمية
أعرض في EDS

Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.

التفاصيل البيبلوغرافية
العنوان: Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
المؤلفون: Wlodarska M; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Luo C; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., Kolde R; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., d'Hennezel E; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Annand JW; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Heim CE; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Krastel P; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Schmitt EK; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Omar AS; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Creasey EA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., Garner AL; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mohammadi S; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., O'Connell DJ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Abubucker S; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Arthur TD; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Franzosa EA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Huttenhower C; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Murphy LO; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Haiser HJ; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Vlamakis H; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Porter JA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Xavier RJ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: xavier@molbio.mgh.harvard.edu.
المصدر: Cell host & microbe [Cell Host Microbe] 2017 Jul 12; Vol. 22 (1), pp. 25-37.e6.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, Mass. : Cell Press
مواضيع طبية MeSH: Symbiosis*, Indoles/*metabolism , Indoles/*pharmacology , Inflammation/*metabolism , Intestinal Mucosa/*microbiology , Peptostreptococcus/*metabolism, Animals ; Anti-Inflammatory Agents/pharmacology ; Bacteria/classification ; Bacteria/genetics ; Bacteria/metabolism ; Bacteroides/genetics ; Bacteroides/metabolism ; Clostridiales/genetics ; Clostridiales/metabolism ; Colon/microbiology ; Colon/pathology ; Cytokines/metabolism ; Dysbiosis/metabolism ; Humans ; Inflammatory Bowel Diseases ; Intestinal Mucosa/injuries ; Intestinal Mucosa/metabolism ; Intestines/microbiology ; Mice ; Mucin-2/genetics ; Mucin-2/metabolism ; Mucins/genetics ; Mucins/metabolism ; Organoids
مستخلص: Host factors in the intestine help select for bacteria that promote health. Certain commensals can utilize mucins as an energy source, thus promoting their colonization. However, health conditions such as inflammatory bowel disease (IBD) are associated with a reduced mucus layer, potentially leading to dysbiosis associated with this disease. We characterize the capability of commensal species to cleave and transport mucin-associated monosaccharides and identify several Clostridiales members that utilize intestinal mucins. One such mucin utilizer, Peptostreptococcus russellii, reduces susceptibility to epithelial injury in mice. Several Peptostreptococcus species contain a gene cluster enabling production of the tryptophan metabolite indoleacrylic acid (IA), which promotes intestinal epithelial barrier function and mitigates inflammatory responses. Furthermore, metagenomic analysis of human stool samples reveals that the genetic capability of microbes to utilize mucins and metabolize tryptophan is diminished in IBD patients. Our data suggest that stimulating IA production could promote anti-inflammatory responses and have therapeutic benefits.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
References: Gut Microbes. 2016;7(2):115-25. (PMID: 26963626)
Bioinformatics. 2015 Jan 15;31(2):166-9. (PMID: 25260700)
Cell. 2016 Dec 1;167(6):1469-1480.e12. (PMID: 27912057)
World J Gastroenterol. 2009 Nov 14;15(42):5287-94. (PMID: 19908336)
Cell. 2016 Nov 17;167(5):1339-1353.e21. (PMID: 27863247)
Biochem Pharmacol. 2008 Dec 1;76(11):1485-9. (PMID: 18694732)
Gastroenterology. 2011 Jul;141(1):237-48, 248.e1. (PMID: 21600206)
Science. 2005 Mar 25;307(5717):1955-9. (PMID: 15790854)
Genome Res. 2002 Apr;12(4):656-64. (PMID: 11932250)
J Med Invest. 2012;59(1-2):79-94. (PMID: 22449996)
Science. 2014 Sep 12;345(6202):1254009. (PMID: 25214634)
Biochem Pharmacol. 2010 Dec 15;80(12 ):1895-903. (PMID: 20643109)
Nat Methods. 2012 Mar 04;9(4):357-9. (PMID: 22388286)
Int J Syst Evol Microbiol. 2004 Sep;54(Pt 5):1469-76. (PMID: 15388697)
Immunity. 2013 Aug 22;39(2):372-85. (PMID: 23973224)
BMC Bioinformatics. 2012 Jun 18;13:134. (PMID: 22708584)
Cell Host Microbe. 2011 Nov 17;10(5):507-14. (PMID: 22036470)
Nat Med. 2016 Jun;22(6):598-605. (PMID: 27158904)
Am J Gastroenterol. 2010 Nov;105(11):2420-8. (PMID: 20648002)
J Biol Chem. 2009 Jul 3;284(27):18445-57. (PMID: 19403529)
Nature. 2012 Jun 13;486(7402):207-14. (PMID: 22699609)
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9. (PMID: 18806221)
Genome Biol. 2014 Feb 03;15(2):R29. (PMID: 24485249)
Nature. 2014 Oct 30;514(7524):638-41. (PMID: 25274297)
Gut. 2014 Feb;63(2):281-91. (PMID: 23426893)
Cell Host Microbe. 2013 Aug 14;14(2):207-15. (PMID: 23954159)
Mol Microbiol. 2002 Apr;44(1):49-60. (PMID: 11967068)
Cell. 2016 May 5;165(4):842-53. (PMID: 27133167)
Science. 2012 Jun 8;336(6086):1268-73. (PMID: 22674334)
Science. 2016 Jun 24;352(6293):1535-42. (PMID: 27339979)
Cell Syst. 2016 May 25;2(5):323-334. (PMID: 27211859)
Infect Immun. 1992 Oct;60(10):3971-8. (PMID: 1398908)
J Invest Dermatol. 2012 Jan;132(1):59-68. (PMID: 21753779)
Immunity. 2014 Aug 21;41(2):296-310. (PMID: 25065623)
Nat Rev Microbiol. 2011 Apr;9(4):265-78. (PMID: 21407243)
Chem Biol. 2010 May 28;17 (5):537-47. (PMID: 20534351)
Inflamm Bowel Dis. 2011 Nov;17(11):2299-307. (PMID: 21290483)
Nucleic Acids Res. 2016 Jul 8;44(W1):W83-9. (PMID: 27098042)
Nat Protoc. 2013 Dec;8(12):2471-82. (PMID: 24232249)
Nat Methods. 2013 Nov;10(11):1096-8. (PMID: 24056875)
Curr Protoc Immunol. 2012 Nov;Chapter 7:Unit7.32. (PMID: 23129155)
Cell Host Microbe. 2008 Nov 13;4(5):447-57. (PMID: 18996345)
Science. 2011 Jan 21;331(6015):337-41. (PMID: 21205640)
BMC Bioinformatics. 2010 Mar 08;11:119. (PMID: 20211023)
Toxicol Sci. 2009 Oct;111(2):199-201. (PMID: 19628587)
Eur J Pharmacol. 2008 Mar 10;581(3):315-23. (PMID: 18215658)
Gut. 1998 Apr;42(4):485-92. (PMID: 9616308)
Am J Gastroenterol. 2014 Mar;109(3):395-400. (PMID: 24419484)
Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792)
J Mol Biol. 1990 Oct 5;215(3):403-10. (PMID: 2231712)
PLoS One. 2010 Aug 18;5(8):e12238. (PMID: 20805871)
Cell Host Microbe. 2014 Mar 12;15(3):382-392. (PMID: 24629344)
Cell. 2014 Feb 27;156(5):1045-59. (PMID: 24581500)
Hepatogastroenterology. 2008 Mar-Apr;55(82-83):394-7. (PMID: 18613373)
Genome Biol. 2009;10(3):R25. (PMID: 19261174)
Front Genet. 2015 Mar 19;6:81. (PMID: 25852737)
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703. (PMID: 19234110)
Arch Biochem Biophys. 2014 Sep 1;557:36-46. (PMID: 24914470)
Nat Microbiol. 2016 Jan 27;1:15021. (PMID: 27571978)
Nat Med. 2015 Aug;21(8):895-905. (PMID: 26214836)
Nature. 2012 Jul 25;487(7408):477-81. (PMID: 22837003)
Nat Commun. 2015 Jul 08;6:7624. (PMID: 26154892)
Am J Gastroenterol. 2011 Aug;106(8):1544-55. (PMID: 21519361)
Gastroenterology. 2013 Feb;144(2):357-368.e9. (PMID: 23123183)
Cell Host Microbe. 2015 Feb 11;17(2):260-73. (PMID: 25662751)
Nature. 2009 Jan 22;457(7228):480-4. (PMID: 19043404)
Nucleic Acids Res. 2014 Jan;42(Database issue):D617-24. (PMID: 24203705)
معلومات مُعتمدة: P30 DK043351 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Muc2; Peptostreptococcus; indoleacrylic acid; indolepropionic acid; mucus; organoid
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Cytokines)
0 (Indoles)
0 (Mucin-2)
0 (Mucins)
83X500J040 (indoleacrylic acid)
تواريخ الأحداث: Date Created: 20170714 Date Completed: 20180307 Latest Revision: 20200930
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5672633
DOI: 10.1016/j.chom.2017.06.007
PMID: 28704649
قاعدة البيانات: MEDLINE
الوصف
تدمد:1934-6069
DOI:10.1016/j.chom.2017.06.007